Chemical Sampling Information
	N-Nitrosomorpholine
Quick Links General Description Health Factors Monitoring Search    [use word(s)/phrase ] Table of Contents By Name A B C D E F G H I J K L M N O P Q R S T U V W X Y Z By CAS Number General Description Synonyms: NMOR; 4-Nitrosomorpholine; 4-Nitroso-morpholine OSHA IMIS Code Number: 1943 Chemical Abstracts Service (CAS) Registry Number: 59-89-2 NIOSH, Registry of Toxic Effects (RTECS) Identification Number: QE7525000 Chemical Description and Physical Properties: yellow solid molecular formula: C4H8N2O2 molecular weight: 116.1 boiling point: 224°C/747 mm Hg melting point: 29°C Health Factors National Toxicology Program (NTP) carcinogenic classification: Reasonably Anticipated to be Human Carcinogen [217 KB PDF] International Agency for Research on Cancer (IARC) carcinogenic classification: Group 2B, possibly carcinogenic to humans Potential symptoms: Irritation of eyes, skin; in animals: liver damage; [potential occupational carcinogen] Health Effects: Animal carcinogen (liver, lung, esophagus, nasal/paranasal) (HE2). Affected organs: Liver (rats); lungs (mice) Notes: N-Nitrosomorpholine is an OSHA Select Carcinogen. OSHA does not have a PEL for this chemical. Activation of N-nitrosomorpholine to a mutagenic metabolite in Salmonella was reported to be catalyzed by cytochrome P450 2A6 (major) and P450 2E1 (minor). Occupational exposure to this chemical occurs primarily in the rubber industry. However, an increase in the urinary excretion of N-nitrosomorpholine can be caused by consumption of food rich in nitrate and amines. Date Last Revised: 06/05/2006 Literature Basis: No Author: N-Nitrosomorpholine, CAS No. 59-89-2. Report on Carcinogens, Eleventh Edition; U.S. Department of Health and Human Services, Public Health Service, National Toxicology Program, 2005. [217 KB PDF] Fujita, K. and Kamataki, T.: Predicting the mutagenicity of tobacco-related N-nitrosamines in humans using 11 strains of Salmonella typhimurium YG7108, each coexpressing a form of human cytochrome P450 along with NADPH-cytochrome P450 reductase. Environ. Mol. Mutagen. 38(4): 339-346, 2001. Hecht, S.S., Lijinsky, W., Kovatch, R.M., Chung, F.L. and Saavedra, J.E.: Comparative tumorigenicity of N-nitroso-2-hydroxymorpholine, N-nitrosodiethanolamine and N-nitrosomorpholine in A/J/ mice and F344 rats. Carcinogenesis 10(8): 1475-1477, 1989. Monarca, S., et al.: Monitoring airborne genotoxicants in the rubber industry using genotoxicity tests and chemical analyses. Mutat. Res. 490(2): 159-169, 2001. van Maanen, J.M., Pachen, D.M., Dallinga, J.W. and Kleinjans, J.C.: Formation of nitrosamines during consumption of nitrate- and amine-rich foods, and the influence of the use of mouthwashes. Cancer Detect. Prev. 22(3): 204-212, 1998. Monitoring Methods used by OSHA Laboratory Sampling/Analytical Method: sampling media: ThermoSorb/N Tube analytical solvent: (75:25) Dichloromethane:Methanol maximum volume: 75 Liters   maximum flow rate: 1.0 L/min current analytical method: Gas Chromatography; GC/TEA method reference: OSHA Analytical Method (OSHA 27) method classification: Fully Validated note: OSHA personnel may obtain ThermoSorb/N Tube from SLTC. Store samples in freezer. Bulk method: Limit the amount of bulk submitted to one gram or one mL. All Trademarks are the property of their respective owners. Accessibility Assistance: Contact the OSHA Directorate of Science, Technology and Medicine at 202-693-2300 for assistance accessing PDF materials.