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Chemical Sampling Information |
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| N-Nitrosodiphenylamine |
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General Description
Synonyms: NDPA; Diphenyl nitrosamine; Redax; Vulcatard; NDFA
OSHA IMIS Code Number: N109
Chemical Abstracts Service (CAS) Registry Number: 86-30-6
NIOSH, Registry of Toxic Effects (RTECS) Identification Number: JJ9800000
Chemical Description and Physical Properties: Yellow flakes
molecular formula: C12H10N2O
molecular weight: 198.24
boiling point: 101°C
melting point: 66.5°C
Potentially hazardous incompatibilities: Reacts vigorously with oxidants.
Health Factors
International Agency for Research on Cancer (IARC) carcinogenic classification: Group 3, Not classifiable as to its carcinogenicity to humans
Environmental Protection Agency (EPA) carcinogenic classification: Group B2, Probable human carcinogen.
Potential symptoms: Unknown in humans
Health Effects: Unknown in humans; animal carcinogen (bladder cancer) (HE2)
Affected organs: Urinary bladder (in rodents).
Notes:
- OSHA does not have a PEL for N-nitrosodiphenylamine.
- Major metabolites in urine include 4-hydroxydiphenylamine and 4,4'-dihydroxydiphenylamine, indicating a denitrosation to diphenylamine and nitric oxide, with subsequent hydroxylation of the diphenylamine. Nitrate and nitrite are further metabolites (of nitric oxide) that have been identified in rat urine.
Date Last Revised: 11/23/2005
Literature Basis:
- International Chemical Safety Cards (WHO/IPCS/ILO): N-Nitrosodiphenylamine.
- U.S. EPA Integrated Risk Information System: N-Nitrosodiphenylamine (CASRN 86-30-6).
- McGregor, D.: The genetic toxicology of N-nitrosodiphenylamine. Mutation Res. 317(3): 195-211, 1994.
- Pohanish, R.P. (editor): N-Nitrosodiphenylamine. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 2. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 1733-1735.
Monitoring Methods used by OSHA
Laboratory Sampling/Analytical Method:
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sampling media: Midget Fritted Glass Bubbler (MFGB) containing 15 mL Isopropanol
maximum volume: 250 Liters maximum flow rate: 1.0 L/min
current analytical method: High Performance Liquid Chromatography; HPLC/UV
method reference: OSHA Analytical Method (OSHA 23)
method classification: Fully Validated
note: The samples must be protected from light during and after sampling. Wrap Bubbler with black tape to protect from light. Samples must be either stored in a freezer and shipped frozen or analyzed within six days after collection.
analytical condition: Column: CN; Mobile Phase: 60:40 Methanol:Water; Detector Wavelength: 280nm; Detection Limit: 3.5 ug/m3
Bulk method: Limit the amount of bulk submitted to one gram or one mL.
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