Chemical Sampling Information
	morpholine
Quick Links General Description Exposure Limits Health Factors Monitoring Search    [use word(s)/phrase] Table of Contents By Name A B C D E F G H I J K L M N O P Q R S T U V W X Y Z By CAS Number General Description Synonyms: Diethyleneimide oxide; Diethylene imidoxide; Diethylene oximide; Tetrahydro-1,4-oxazine; Tetrahydro-p-oxazine OSHA IMIS Code Number: 1797 Chemical Abstracts Service (CAS) Registry Number: 110-91-8 NIOSH, Registry of Toxic Effects (RTECS) Identification Number: QD6475000 Department of Transportation Regulation Number (49 CFR 172.101) and Guide: 2054 132 [27 KB, PDF] NIOSH Pocket Guide to Chemical Hazards, Morpholine: chemical description, physical properties, potentially hazardous incompatibilities, and more Exposure Limits OSHA Permissible Exposure Limit (PEL) for General Industry: 29 CFR 1910.1000 Z-1 Table -- 20 ppm, 70 mg/m3 TWA; Skin OSHA Permissible Exposure Limit (PEL) for Construction Industry: 29 CFR 1926.55 Appendix A -- 20 ppm, 70 mg/m3 TWA; Skin OSHA Permissible Exposure Limit (PEL) for Maritime: 29 CFR 1915.1000 Table Z-Shipyards -- 20 ppm, 70 mg/m3 TWA; Skin American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 20 ppm, 71 mg/m3 TWA; Skin; Appendix A4 - Not Classifiable as a Human Carcinogen National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 20 ppm, 70 mg/m3 TWA; 30 ppm, 105 mg/m3 STEL; Skin Health Factors International Agency for Research on Cancer (IARC) carcinogenic classification: Group 3, not classifiable as to its carcinogenicity to humans. [62 KB, PDF] NIOSH Immediately Dangerous To Life or Health Concentration (IDLH): 1,400 ppm Potential symptoms: Irritation of eyes, skin, nose, respiratory system; visual disturbance cough, shortness of breath, labored breathing, pulmonary edema (may be delayed); in animals: liver, kidney damage; SKIN ABS.: Redness, pain, burns, blisters; INGES. ACUTE: Abdominal pain, burning sensation; nausea, vomiting, diarrhea; shock or collapse. Health Effects: Irritation–Eye, Nose, Throat, Skin---severe (HE14) Cumulative liver and kidney damage (HE3) Affected organs: Eyes, skin, respiratory system, liver, kidneys Notes: Explosive vapor/air mixtures of morpholine may be formed above 35°C. NIOSH’s IDLH for morpholine is 10% of its lower explosive limit. Morpholine is listed among FDA’s “secondary direct food additives permitted in food for human consumption” (except in milk and milk products) as a boiler water additive not to exceed 10 ppm in steam (21 CFR 173.310). In animal studies, morpholine was excreted largely unchanged in the urine, showing major metabolite formation (~20% N-methylmorpholine-N-oxide) only in guinea pigs. Plasma elimination half-lives ranged from 2 hours in hamsters to 5 hours in guinea pigs. Date Last Revised: 04/17/2007 Literature Basis: NIOSH Pocket Guide to Chemical Hazards: Morpholine. International Chemical Safety Cards (WHO/IPCS/ILO): Morpholine. [No authors listed]: Morpholine. IARC Monogr. Eval. Carcinog. Risks Hum. 47: 199-213, 1989. [62 KB, PDF] Pohanish, R.P. (editor): Morpholine. In, Sittig’s Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 2. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 1639-1641. Monitoring Methods used by OSHA Laboratory Sampling/Analytical Method: sampling media: XAD-7 tube (coated with 10% phosphoric acid) (80/40 mg sections, 20/40 mesh) analytical solvent: 1 mL 20:80 water:methanol, shake 0.5 hour, then 0.5 mL removed and added to 0.5 mL 20:80 1 N NaOH:methanol maximum volume: 10 Liters   maximum flow rate: 0.1 L/min current analytical method: Gas Chromatography; GC/FID method reference: OSHA Manual of Analytical Methods (OSHA PV2123) method classification: Partially Validated On-Site Sampling Techniques/Methods: device: Instrumentation manufacturer: Infrared Spectrophotometer model/type: MIRAN 1A & 1B sampling information: 0.7 ppm @ 9.1 um method reference: on-site air secondary (manufacturer) device: Instrumentation manufacturer: Infrared Spectrophotometer model/type: MIRAN 103 sampling information: 0-100 ppm @ 9.0 um method reference: on-site air secondary (manufacturer) All Trademarks are the property of their respective owners. Accessibility Assistance: Contact the OSHA Directorate of Science, Technology and Medicine at 202-693-2300 for assistance accessing PDF materials.