||Chemical Sampling Information
|Methyl Ethyl Ketoxime
Synonyms: Ethyl methyl ketone oxime; Ethyl methyl ketoxime; MEK oxime; 2-Butanone, oxime; USAF AM-3; USAF DO-44; USAF EK-906; Skino #2; Troykyd anti-skin B
OSHA IMIS Code Number: R250
Chemical Abstracts Service (CAS) Registry Number: 96-29-7
Chemical Description and Physical Properties: Clear, colorless to light yellow liquid; odor varies from a hardly discernible ethereal aroma to an unpleasant aromatic aroma.
molecular formula: C4H9NO
molecular weight: 87.13
boiling point: 152°C
vapor pressure: <1.07 mmHg @ 20°
flash point: 59°C
Potential symptoms: In animals: Irritation of mucus membranes; CNS depression; methemoglobinemia; anemia, enlarged spleen
Health Effects: No human studies were found. In animals: Anemia (HE12); Methemoglobinemia (HE13); Narcosis (HE8). Suspected animal carcinogen (HE2).
Affected organs: Blood, liver, CNS
- OSHA does not have a PEL for methyl ethyl ketoxime.
- Unit risk estimates of 2.53 x 10-6 per µg/m3 and 1.13 x 10-6 µg/m3 have been calculated from incidences of liver adenoma and liver carcinoma, respectively, in inhalational toxicity studies with rats.
- Liver tumors in rats and mice appeared late in life during chronic inhalation studies with methyl ethyl ketoxime and apparently did not shorten their lifespans.
- Radiolabeled methyl ethyl ketoxime was metabolized in rats to carbon dioxide, as well as to expired volatiles, a major component being methyl ethyl ketone. Urine contained 13-26% of the radiolabel.
- Subacute inhalational toxicology studies with mice indicated a NOEL of 3 ppm for olfactory degeneration in the nasal turbinates.
Date Last Revised: 09/01/2006
Monitoring Methods used by OSHA
- Burka, L.T., Black, S.R. and Mathews, J.M.: Disposition of methyl ethyl ketoxime in the rat after oral, intravenous and dermal administration. Xenobiotica 28(10): 1005-1015, 1998.
- Newton, P.E., Bolte, H.F., Derelanko, M.J., Hardisty, J.F. and Rinehart, W.E.: An evaluation of changes and recovery in the olfactory epithelium in mice after inhalation exposure to methylethylketoxime. Inhal. Toxicol. 14(12): 1249-1260, 2002.
- Newton, P.E., Wooding, W.L., Bolte, H.F., Derelanko, M.J., Hardisty, J.F. and Rinehart, W.E.: A chronic inhalation toxicity/oncogenicity study of methylethylketoxime in rats and mice. Inhal. Toxicol. 13(12): 1093-1116, 2001.
- Schuhmacher-Wolz, U., Konietzka, R. and Schneider, K.: Using carcinogenic potency ranking to assign air contaminants to emission classes. Regul. Toxicol. Pharmacol. 36(3): 221-233, 2002.
- Schulze, G.E. and Derelanko, M.J.: Assessing the neurotoxic potential of methyl ethyl ketoxime in rats. Fundam. Appl. Toxicol. 21(4): 476-485, 1993.
Laboratory Sampling/Analytical Method:
sampling media: XAD-4 (80/40 mg section)
analytical solvent: (95:5) Methylene Chloride:Methanol
maximum volume: 10 Liters maximum flow rate: 0.1 L/min
current analytical method: Gas Chromatography : GC/FID
method reference: OSHA SLTC In-House File
method classification: Not Validated
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