Chemical Sampling Information
	methylcyclopentadienyl manganese tricarbonyl
Quick Links General Description Exposure Limits Health Factors Monitoring Search    [use word(s)/phrase] Table of Contents By Name A B C D E F G H I J K L M N O P Q R S T U V W X Y Z By CAS Number General Description Synonyms: CI-2; Combustion Improver-2; Manganese tricarbonylmethylcyclopentadienyl; 2-methylcyclopentadienyl manganese tricarbonyl; MMT OSHA IMIS Code Number: 1767 Chemical Abstracts Service (CAS) Registry Number: 12108-13-3 Additional Chemical Abstracts Service (CAS) Registry Number: 7439-96-5 (Manganese compounds (as Mn)) NIOSH, Registry of Toxic Effects (RTECS) Identification Number: OP1450000 NIOSH Pocket Guide to Chemical Hazards, Methyl cyclopentadienyl manganese tricarbonyl (as Mn): chemical description, physical properties, potentially hazardous incompatibilities, and more Exposure Limits OSHA Permissible Exposure Limit (PEL) for General Industry: 29 CFR 1910.1000 Z-1 Table -- 5 mg/m3 Ceiling (PEL listed under Manganese compounds (as Mn)) OSHA Permissible Exposure Limit (PEL) for Construction Industry: 29 CFR 1926.55 Appendix A -- 5 mg/m3 Ceiling (PEL listed under Manganese compounds (as Mn)) OSHA Permissible Exposure Limit (PEL) for Maritime: 29 CFR 1915.1000 Table Z-Shipyards -- 5 mg/m3 Ceiling (PEL listed under Manganese compounds (as Mn)) American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 0.2 mg/m3 TWA; Skin; (TLV listed under 2-Methylcyclopentadienyl manganese tricarbonyl, as Mn) National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 0.2 mg/m3 TWA; Skin Health Factors Potential symptoms: Eye irritation; dizziness, giddiness, nausea, headache; cough, sore throat, labored breathing (dyspnea); in animals: tremor, severe clonic spasms, lassitude (weakness, exhaustion), slow respiration; lung, liver, kidney injury; SKIN ABS: skin redness, burning sensation. Health Effects: Acute CNS effects (HE4); Cumulative liver and kidney damage (HE3) Irritation-Eye---Moderate (HE15) Affected organs: Eyes, CNS, liver, kidneys Notes: The acute injection of MMT into rats causes pulmonary edema localized to the lung alveoli, which is thought to be produced by a toxic metabolite formed in the lungs, possibly by cytochrome P450 2B1. It is not known whether this bioactivation occurs in human lungs. Compounds emitted from the vehicular combustion of MMT as a gasoline additive include manganese oxide, phosphate and sulfate. Studies in rats report that these compounds, upon inhalation, can be taken up by olfactory nerve endings in the nose and retrogradely transported back into the brain, causing endogenous manganese levels in some areas (e.g., globus pallidus, striatum) to be more than doubled. It has been suggested that the convulsive effect of MMT in mice is due to an inhibitory effect at the GABA(A) receptor-linked chloride channel. Date Last Revised: 06/10/2005 Literature Basis: NIOSH Pocket Guide to Chemical Hazards: Methyl cyclopentadienyl manganese tricarbonyl (as Mn). International Chemical Safety Cards (WHO/IPCS/ILO): Methylcyclopentadienyl manganese tricarbonyl. Blanchard, K.T., Clay, R.J. and Morris, J.B.: Pulmonary activation and toxicity of cyclopentadienyl manganese tricarbonyl. Toxicol. Appl. Pharmacol. 136(2): 280-288, 1996. Fishman, B.E., McGinley, P.A. and Gianutsos, G.: Neurotoxic effects of methylcyclopentadienyl manganese carbonyl (MMT) in the mouse: basis of MMT-induced seizure activity. Toxicology 45(2): 193-201, 1987. Normandin, L., et al.: Manganese distribution in the brain and neurobehavioral changes following inhalation exposure of rats to three chemical forms of manganese. Neurotoxicology 25(3): 433-441, 2004. Pohanish, R.P. (editor): Manganese, Tricarbonyl Methylcyclopentadienyl. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 2. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 1450-1451. Verschoyle, R.D., Wolf, C.R. and Dinsdale, D.: Cytochrome P450 2B isozymes are responsible for the pulmonary bioactivation and toxicity of butylated hydroxytoluene, O,O,S-trimethylphosphorothioate and methylcyclopentadienyl manganese tricarbonyl. J. Pharmacol. Exp. Ther. 266(2): 958-963, 1993. Monitoring Methods used by OSHA Laboratory Sampling/Analytical Method: sampling media: XAD-2 Tubes (80/40 mg sections) maximum volume: 10 Liters   maximum flow rate: 0.2 L/min current analytical method: Gas Chromatography; GC/ECD method reference: OSHA SLTC In-House File method classification: Not Validated article: "Analyst", February 1992, Vol 117, pp 161-164. All Trademarks are the property of their respective owners.