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Chemical Sampling Information |
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| Methylcyclohexane |
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General Description
Synonyms: Cyclohexylmethane; Hexahydrotoluene
OSHA IMIS Code Number: 1740
Chemical Abstracts Service (CAS) Registry Number: 108-87-2
NIOSH, Registry of Toxic Effects (RTECS) Identification Number: GV6125000
Department of Transportation Regulation Number (49 CFR 172.101) and Guide: 2296 128 [27 KB PDF]
NIOSH Pocket Guide to Chemical Hazards, Methylcyclohexane: chemical description, physical properties, potentially hazardous incompatibilities, and more
Exposure Limits
OSHA Permissible Exposure Limit (PEL) for General Industry: 29 CFR 1910.1000 Z-1 Table -- 500 ppm, 2000 mg/m3 TWA
OSHA Permissible Exposure Limit (PEL) for Construction Industry: 29 CFR 1926.55 Appendix A -- 500 ppm, 2000 mg/m3 TWA
OSHA Permissible Exposure Limit (PEL) for Maritime: 29 CFR 1915.1000 Table Z-Shipyards -- 500 ppm, 2000 mg/m3 TWA
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 400 ppm, 1610 mg/m3 TWA
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 400 ppm, 1600 mg/m3 TWA
Health Factors
NIOSH Immediately Dangerous To Life or Health Concentration (IDLH): 1,200 ppm [LEL]
Potential symptoms: Irritation of eyes, skin, respiratory system; dizziness, drowsiness; in animals: narcosis; chemical pneumonia (by aspiration of liquid); INGES. ACUTE: Nausea.
Health Effects: Irritation-Eye, Nose, Throat, Skin---Mild (HE16); Narcosis (HE8)
Affected organs: Eyes, skin, respiratory system, CNS
Notes:
- Vapor/air mixtures may be explosive. NIOSH’s IDLH is 10% of the lower explosive limit of methylcyclohexane.
- The urinary metabolites of orally administered methylcyclohexane in rabbits and rats are glucuronide conjugates of several hydroxylated derivatives. The most common metabolite in the rabbit is trans-4-methylcyclohexanol, and the most common in the rat is 2(trans)-hydroxy-4(cis)-methylcyclohexanol.
- The amount of methylcyclohexane in JP-4 jet fuel (>7%) is much greater than in automotive gasoline (0.46-0.58 %).
Date Last Revised: 06/21/2006
Literature Basis:
- NIOSH Pocket Guide to Chemical Hazards: Methylcyclohexane.
- International Chemical Safety Cards (WHO/IPCS/ILO): Methylcyclohexane.
- Elliott, T.H., Tao, R.C.C. and Williams, R.T.: The metabolism of methylcyclohexane. Biochem. J. 95: 70-76, 1965.
- Parnell, M.J., Henningsen, G.M., Hixson, C.J., Yu, K.O., McDonald, G.A. and Serve, M.P.: The metabolism of methylcyclohexane in Fischer 344 rats. Chemosphere 17(7): 1321-1327, 1988.
- Pohanish, R.P. (editor): Methylcyclohexane. In, Sittig’s Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 2. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 1546-1547.
- No author: Identifying hydrocarbons. In, Forensics Primer: An Introduction to Environmental Forensic Geochemistry. ZymaX Forensics, Division of ZymaX™ Envirotechnology, Inc.
Monitoring Methods used by OSHA
Laboratory Sampling/Analytical Method:
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sampling media: Charcoal Tube (100/50 mg sections, 20/40 mesh)
analytical solvent: Carbon Disulfide
maximum volume: 4 Liters maximum flow rate: 0.2 L/min
current analytical method: Gas Chromatography; GC/FID
method reference: NIOSH Analytical Method (NIOSH 1500) [128 KB, PDF]
method classification: Fully Validated
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