Synonyms: EGMEA; Ethylene glycol monomethyl ether acetate; Glycol monomethyl ether acetate; 2-Methoxyethanol acetate; Methyl Cellosolve® acetate

OSHA IMIS Code Number: 1170

IMIS Name History: Methyl Cellosolve® acetate prior to 7/26/2005

Chemical Abstracts Service (CAS) Registry Number: 110-49-6

NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: KL5950000

Department of Transportation Regulation Number (49 CFR 172.101) and Guide: 1189 129

NIOSH Pocket Guide to Chemical Hazards, Methyl Cellosolve® acetate: chemical description, physical properties, potentially hazardous incompatibilities, and more

OSHA Permissible Exposure Limit (PEL):

General Industry: 29 CFR 1910.1000 Z-1 Table -- 25 ppm, 120 mg/m³ TWA; Skin

Construction Industry: 29 CFR 1926.55 Appendix A -- 25 ppm, 120 mg/m³ TWA; Skin

Maritime: 29 CFR 1915.1000 Table Z-Shipyards -- 25 ppm, 120 mg/m³ TWA; Skin

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV) : 0.1 ppm, 0.5 mg/m³ TWA; Skin

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 0.1 ppm, 0.5 mg/m³ TWA; Skin

NIOSH Immediately Dangerous To Life or Health Concentration (IDLH): 200 ppm

Potential Symptoms: Eye, nose, and throat irritation; coughing, shortness of breath, pulmonary edema; kidney, brain damage; dizziness, drowsiness, headache; dry skin; in animals: narcosis; reproductive, teratogenic effects; SKIN ABS; INGES ACUTE: Abdominal pain, nausea, vomiting; weakness; unconsciousness.

Health Effects: Irritiation-Eyes, Nose, Throat, Skin---Mild (HE16); Blood disorders (HE12); CNS effects (HE7); Kidney damage (HE3); Suspected reproductive effects (HE5).

Affected Organs: Eyes, respiratory system, kidneys, brain, CNS, PNS, reproductive system, hematopoietic system.

Notes:

1. The acetate ester is rapidly converted in the body to methyl cellusolve (2-methoxyethanol), which is further metabolized to aldehyde and acid metabolites that are thought to be involved in reproductive and developmental toxicity, including teratogenicity (see file for Methyl Cellosolve).

Literature Basis:

• NIOSH Pocket Guide to Chemical Hazards: Methyl Cellosolve® acetate.
• International Chemical Safety Cards (WHO/IPCS/ILO): 2-Methoxyethyl Acetate.
• Johanson, G.: Toxicity review of ethylene glycol monomethyl ether and its acetate ester. Crit. Rev. Toxicol. 30(3): 307-345, 2000.
• Pohanish, R.P. (editor): Methoxyethyl Acetate. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 2. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 1507-1509.

Date Last Revised: 12/14/2004

Primary Laboratory Sampling/Analytical Method (SLC1):

• sampling media: Charcoal Tube (100/50 mg sections, 20/40 mesh)
  analytical solvent: (95:5) Methylene Chloride:Methanol
  maximum volume: 10 Liters
  maximum flow rate: 0.1 L/min
  current analytical method: Gas Chromatography; GC/FID
  method reference: OSHA Analytical Method (OSHA 53)
  method classification: Fully Validated
  note: Samples for 2-methoxyethyl acetate and/or for 2-ethoxyethyl acetate should be refrigerated upon receipt at the analytical laboratory.
  
  
• sampling media: Charcoal Tube (100/50 mg sections, 20/40 mesh)
  analytical solvent: (95:5) Methylene Chloride:Methanol
  maximum volume: 48 Liters
  maximum flow rate: 0.1 L/min (long term)
  maximum volume: 15 Liters
  maximum flow rate: 0.1 L/min (short term)
  current analytical method: Gas Chromatography; GC/FID
  method reference: OSHA Analytical Method (OSHA 79)
  method classification: Fully Validated
  note: Use these larger maximum volumes to monitor sub-ppm levels. Samples for 2-methoxyethyl acetate and/or for 2-ethoxyethyl acetate should be refrigerated upon receipt at the analytical laboratory.

Wipe Sampling Method:

• sampling media: charcoal pad
  note: Seal in glass vial for shipment.

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