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Chemical Sampling Information (CSI)
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General Description

Synonyms: Manganese oxide; Manganomanganic oxide; Trimanganese tetraoxide; Trimanganese tetroxide

OSHA IMIS Code Number: M101

Chemical Abstracts Service (CAS) Registry Number: 1317-35-7

NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: OP0895000

NIOSH Pocket Guide to Chemical Hazards, Manganese Tetroxide (as Mn): chemical description, physical properties, potentially hazardous incompatibilities, and more

Exposure Limits

OSHA Permissible Exposure Limit (PEL):
General Industry: 29 CFR 1910.1000 Z-1 Table -- 5 mg/m3 Ceiling [PEL listed under Manganese Compounds (as Mn) and Manganese Fume (as Mn)]

Construction Industry: 29 CFR 1926.55 Appendix A -- 5 mg/m3 Ceiling [PEL listed under Manganese Compounds (as Mn) and Manganese Fume (as Mn)]

Maritime: 29 CFR 1915.1000 Table Z-Shipyards -- 5 mg/m3 Ceiling [PEL listed under Manganese Compounds (as Mn) and Manganese Fume (as Mn)]
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 0.2 mg/m3 (TLV listed under Manganese and Inorganic Compounds, as Mn)

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 1 mg/m3 TWA; Appendix D - Substances With No Established RELs

Health Factors

Potential symptoms: Asthenia, insomnia, mental confusion; low-back pain; vomiting; malaise, lassitude; kidney damage; cough, pneumonitis; eye, skin redness; neurological and mental disorders (manganism).

Health Effects: Irritation-Eyes, Nose, Throat, Skin---Moderate (HE15); Cumulative CNS damage (HE7); Lung damage---Acute (HE11) and Cumulative (HE10).

Affected organs: Respiratory system, CNS, blood, kidneys.

Notes:
  1. Inhalational toxicokinetic studies with rats indicate achievement of higher levels of manganese in the olfactory bulb and striatal brain areas with Mn sulfate (soluble) than with Mn tetroxide (relatively insoluble).
Date Last Revised: 06/28/2004

Literature Basis:
  • NIOSH Pocket Guide to Chemical Hazards: Manganese Tetroxide (as Mn).
  • International Chemical Safety Cards (WHO/IPCS/ILO): Manganese oxide.
  • EPA Air Toxics Website: Manganese Compounds. U.S. Environmental Protection Agency Technology Transfer Network.
  • Dorman, D.C., Struve, M.F., James, R.A., Marshall, M.W., Parkinson, C.U. and Wong, B.A.: Influence of particle solubility on the delivery of inhaled manganese to the rat brain: manganese sulfate and manganese tetroxide pharmacokinetics following repeated (14-day) exposure. Toxicol. Appl. Pharmacol. 170(2): 79-87, 2001.
Monitoring Methods used by OSHA

Laboratory Sampling/Analytical Method:
  • sampling media: Mixed Cellulose Ester Filter (MCEF) 0.8 microns
    maximum volume: 960 Liters
    minimum volume: 480 Liters
    maximum flow rate: 2.0 L/min
    current analytical method: Atomic Absorption Spectroscopy; AAS
    method reference: OSHA Analytical Method (OSHA ID-121)
    method classification: Fully Validated
    alternate analytical method: Inductively Coupled Argon Plasma; ICP/DCP-AES
    method reference: OSHA Analytical Method (OSHA ID-125G)
    method classification: Fully Validated
    note: Analytical method does not distinguish between dust and fume. When an analysis of a compound is requested, an elemental analysis is performed and reported as Manganese.
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Page last updated: 08/07/2006