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Isopropylamine

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General Description
    Synonym(s): 2-Aminopropane; IPAM; Monoisopropylamine; 2-Propanamine; sec-Propylamine

    OSHA IMIS Code Number: 1562

    Chemical Abstracts Service (CAS) Registry Number: 75-31-0

    NIOSH, Registry of Toxic Effects (RTECS) Identification Number: NT8400000

    Department of Transportation Regulation Number (49 CFR 172.101) and guide [2008 Emergency Response Guidebook, 2.5 MB PDF]: 1221 132

    NIOSH Pocket Guide to Chemical Hazards, Isopropylamine: chemical description, physical properties, potentially hazardous incompatibilities, and more
Exposure Limits
    OSHA Permissible Exposure Limit (PEL) for General Industry: 29 CFR 1910.1000 Z-1 Table -- 5 ppm, 12 mg/m3 (TWA)

    OSHA Permissible Exposure Limit (PEL) for Construction Industry: 29 CFR 1926.55 Appendix A -- 5 ppm, 12 mg/m3 (TWA)

    OSHA Permissible Exposure Limit (PEL) for Maritime: 29 CFR 1915.1000 Table Z-Shipyards -- 5 ppm, 12 mg/m3 (TWA)

    American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 5 ppm, 12 mg/m3 (TWA); 10 ppm, 24 mg/m3 (STEL)

    National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): Appendix D - Substances With No Established RELs
Health Factors
    Potential symptom(s): Eye, nose, throat, skin irritation; pulmonary edema; visual disturbance; skin, eye burns; dermatitis

    Health Effect(s): Irritation-Eye, Nose, Throat, Skin---Marked (HE14)

    Affected organ(s): Respiratory system, skin, eyes

    NIOSH/OSHA/DOE Health Guideline
Monitoring Methods used by OSHA
    Laboratory Sampling/Analytical Method:

    • sampling media: Coated XAD-2 Tube (80/40 sections, 20/60 mesh); coating is 10% (w/w) 1-Naphthylisothiocyanate (NITC)
      analytical solvent: Dimethylformamide
      maximum volume: 20 Liters   maximum flow rate: 1.0 L/min (TWA)
      maximum volume: 1.5 Liters   maximum flow rate: 1.0 L/min (STEL)
      current analytical method: High Performance Liquid Chromatography; HPLV/UV
      method reference: OSHA Analytical Method (OSHA PV2126)
      method classification: Partially Validated


    • sampling media: Midget Fritted Glass Bubbler (MFGB) containing 10 mL of 0.05 M H2SO4.
      maximum volume: 100 Liters   maximum flow rate: 1.0 L/min (TWA)
      maximum volume: 15 Liters   maximum flow rate: 1.0 L/min (STEL)
      current analytical method: Gas Chromatography; GC/FID
      method reference: NIOSH Analytical Method (NIOSH S-147) [281 KB, PDF]
      method classification: Fully Validated

    On-Site Sampling Techniques/Methods:

    • device: Detector Tube
      manufacturer: AUER/MSA
      model/type: Triethylamine-5, MSA P/N 804134, AUER P/N 5086-816
      sampling information: follow manufacturer's instructions
      upper measurement limit: 30 ppm
      detection limit: approximately 1 ppm
      overall uncertainty: unknown
      method reference: on-site air secondary (manufacturer)


    • device: Detector Tube
      manufacturer: Gastec
      model/type: 180
      sampling information: 1 stroke
      upper measurement limit: 110 ppm
      detection limit: 1 ppm
      overall uncertainty: 16.4% for 6 to 22 ppm, 8.2% for 22 to 110 ppm
      method reference: on-site air secondary (manufacturer)

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