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Chemical Sampling Information (CSI)
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General Description

Synonyms: Isopropyl ester of acetic acid; sec-Propyl acetate; 1-Methylethyl ester of acetic acid; 2-Propyl acetate

OSHA IMIS Code Number: 1540

Chemical Abstracts Service (CAS) Registry Number: 108-21-4

NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: AI4930000

Department of Transportation Regulation Number (49 CFR 172.101) and Guide: 1220 129

NIOSH Pocket Guide to Chemical Hazards, Isopropyl Acetate: chemical description, physical properties, potentially hazardous incompatibilities, and more
Exposure Limits

OSHA Permissible Exposure Limit (PEL):
General Industry: 29 CFR 1910.1000 Z-1 Table -- 250 ppm, 950 mg/m3 TWA

Construction Industry: 29 CFR 1926.55 Appendix A -- 250 ppm, 950 mg/m3 TWA

Maritime: 29 CFR 1915.1000 Table Z-Shipyards -- 250 ppm, 950 mg/m3 TWA
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 100 ppm, 418 mg/m3 TWA; 200 ppm, 835 mg/m3 STEL

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): Appendix D - Substances With No Established RELs

Health Factors

NIOSH Immediately Dangerous To Life or Health Concentration (IDLH): 1,800 ppm

Potential Symptoms: Irritation of eyes, nose, skin; cough, sore throat; drowsiness, headache; dry skin, dermatitis; in animals, narcosis; INGES. ACUTE: abdominal pain; dizziness.

Health Effects: Irritation-Eye, Nose, Throat, Skin---Mild (HE16); Narcosis (HE8)

Affected Organs: Eyes, skin, respiratory system, CNS

Notes:
  1. Vapor/air mixtures may be explosive.
  2. Listed among FDA’s “food additives permitted for direct addition to food for human consumption” (21 CFR 172.515).
  3. Isopropyl acetate has been suggested as a less toxic solvent than methyl tert-butyl ether for facilitating the dissolution of cholesterol gall stones, although ethyl propionate was reported to be more effective for dissolving gall stones.
Date Last Revised: 05/25/2006

Literature Basis:
  • NIOSH Pocket Guide to Chemical Hazards: Isopropyl Acetate.
  • International Chemical Safety Cards (WHO/IPCS/ILO): Isopropyl acetate.
  • Pohanish, R.P. (editor): Isopropyl Acetate. In, Sittig’s Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 2. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 1350-1352.
  • Zakko, S.F., Scirica, J.C., Guttermuth, M.C., Dodge, J. and Hajjar, J.-J.: Ethyl propionate is more effective and less cytotoxic than methyl tert-butyl ether for topical gallstone dissolution. Gastroenterology 113(1): 232-237, 1997.
Monitoring Methods used by OSHA

Laboratory Sampling/Analytical Method:
  • sampling media: Charcoal Tube (100/50 mg sections, 20/40 mesh)
    analytical solvent: Carbon Disulfide
    alternate analytical solvent: (99:1) Carbon Disulfide:Dimethylformamide
    alternate analytical solvent: (95:5) Methylene Chloride:Methanol
    maximum volume: 9 Liters
    maximum flow rate: 0.2 L/min (TWA)
    maximum volume: 3 Liters
    maximum flow rate: 0.2 L/min (STEL)
    current analytical method: Gas Chromatography; GC/FID
    method reference: NIOSH Analytical Method (NIOSH 1454) [19 KB PDF, 3 pages]
    method classification: Partially Validated

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Page last updated: 05/11/2007

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