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Chemical Sampling Information |
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| Isophorone Diisocyanate |
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General Description
Synonyms: IPDI; Isocyanic acid, methylene (3,5,5-trimethyl-3,1-cyclohexylene) ester; 3-Isocyanatomethyl-3,5,5-trimethylcyclohexyl-isocyanate; Isophorone diamine diisocyanate
OSHA IMIS Code Number: 1539
Chemical Abstracts Service (CAS) Registry Number: 4098-71-9
NIOSH, Registry of Toxic Effects (RTECS) Identification Number: NQ9370000
Department of Transportation Regulation Number (49 CFR 172.101) and Guide: 2290 156
NIOSH Pocket Guide to Chemical Hazards, Isophorone Diisocyanate: chemical description, physical properties, potentially hazardous incompatibilities, and more
Exposure Limits
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 0.005 ppm, 0.045 mg/m3 TWA
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 0.005 ppm, 0.045 mg/m3 TWA; 0.02 ppm, 0.180 mg/m3 STEL; Skin
Health Factors
Potential symptoms: Irritation of eyes, skin, respiratory system; chest tightness, dyspnea (breathing difficulty); cough, sore throat; bronchitis, wheezing, pulmonary edema, possible respiratory sensitization, asthma;
itching, skin rash.
Health Effects: Respiratory Sensitization---Asthma (HE9); Skin Sensitization (HE3); Irritation-Eye, Nose, Throat, Skin---Marked (HE14)
Affected organs: Eyes, skin, respiratory system
Notes:
- OSHA does not have a PEL for isophorone diisocyanate.
- Detection of isophorone diamine (IPDA) in urine as a biomarker of exposure to isophorone diisocyanate (IPDI) requires hydrolysis of an unidentified conjugate or adduct.
- Following 2 hours of IPDI inhalation by three human volunteers, an average of 27% of the dose was excreted as IPDA in the urine (after hydrolysis), with an average elimination half-time of 2.8 hours (range, 1.7-4.7 hours) for estimated IPDI doses in the 10-43 µg range.
Date Last Revised: 05/19/2006
Literature Basis:
- NIOSH Pocket Guide to Chemical Hazards: Isophorone Diisocyanate.
- International Chemical Safety Cards (WHO/IPCS/ILO): Isophorone diisocyanate.
- Pohanish, R.P. (editor): Isophorone Diisocyanate. In, Sittig’s Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 2. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 1344-1346.
- Tinnerberg, H., Skarping, G., Dalene, M. and Hagmar, L.: Test chamber exposure of humans to 1,6-hexamethylene diisocyanate and isophorone diisocyanate. Int. Arch. Occup. Environ. Health 67(6): 367-374, 1995.
Monitoring Methods used by OSHA
Laboratory Sampling/Analytical Method:
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sampling media: Glass Fiber Filter (37 mm open face) coated with 1.0 mg 1-(2-Pyridyl)piperazine
analytical solvent: (90:10) Acetonitrile:Dimethylsulfoxide
maximum volume: 60 Liters maximum flow rate: 1.0 L/min (TWA)
maximum volume: 15 Liters maximum flow rate: 1.0 L/min (STEL)
current analytical method: High Performance Liquid Chromatography; HPLC/UV/FLU
method reference: OSHA Analytical Methods (OSHA PV2034)
method classification: Partially Validated
note: Refrigerate coated filters until use.
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