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Chemical Sampling Information |
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| Ethyl Methacrylate |
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General Description
Synonyms: Methacrylic acid, ethyl ester; ethyl 2-methylacrylate; ethyl 2-methyl-2-propenoate; Rhoplex AC-33; 2-propenoic acid, 2-methyl-ethyl ester.
OSHA IMIS Code Number: E115
Chemical Abstracts Service (CAS) Registry Number: 97-63-2
NIOSH, Registry of Toxic Effects (RTECS) Identification Number: OZ4550000
Department of Transportation Regulation Number (49 CFR 172.101) and Guide: 2277 130P, inhibited; 2277 130P, stabilized
Chemical Description and Physical Properties: Clear or light yellow liquid, acrylate odor
molecular formula: C6H10O2
molecular weight: 114.14
boiling point: 117°C
vapor pressure: 2 kPa @ 20°C
melting point: -75°C
flash point: 21°C
Health Factors
Potential symptoms: Irritation of eyes, skin, respiratory system; lacrimation; cough, sore throat; dizziness, lightheadedness; sensitization, dermatitis; INGES. ACUTE: Abdominal pain, nausea, vomiting, diarrhea.
Health Effects: Irritation-Eyes, Nose, Throat, Skin---Moderate (HE15);
Affected organs: Eyes, skin, respiratory system, CNS
Notes:
- OSHA does not have a PEL for ethyl methacrylate.
- Vapor/air mixtures may be explosive.
- Patch testing of 243 patients with a history of exposure to various acrylates identified 18 (7.4%) who had an allergic reaction to ethyl methacrylate.
- Irritation of the nasal mucosa may be due in part to hydrolysis of ethyl methacrylate to methacrylic acid by carboxylesterase, high levels of which have been demonstrated in rat olfactory mucosa.
- Treatment of rats with ethyl methacrylate in their drinking water at concentrations of 0.1, 0.2 and 0.5% for 60 days was reported to cause myelinopathy, consisting of clusters of axonal enlargements in the spinal cord and spongiform alterations in white-matter tracts in the brainstem and forebrain, as well as abnormal myelin sheaths in sciatic nerve axons.
Date Last Revised: 06/20/2006
Literature Basis:
- International Chemical Safety Cards (WHO/IPCS/ILO): Ethyl methacrylate.
- Abou-Donia, M.B., et al.: Neurotoxicity of ethyl methacrylate in rats. Toxicol. Environ. Health A 59(2): 97-118, 2000.
- Cosmetic Ingredient Review Expert Panel: Amended final report on the safety assessment of ethyl methacrylate. Int. J. Toxicol. 21(Suppl. 1): 63-79, 2002.
- Kanerva, L., Jolanki, R. and Estlander, T.: 10 years of patch testing with the (meth)acrylate series. Contact Dermatitis 37(6): 255-258, 1997.
- McCarthy, T.J. and Witz, G.: Structure-activity relationships in the hydrolysis of acrylate and methacrylate esters by carboxylesterase in vitro. Toxicology 116(1-3): 153-158, 1997.
- Olson, M.J., Martin, J.L., LaRosa, A.C., Brady, A.N. and Pohl, L.R.: Immunohistochemical localization of carboxylesterase in the nasal mucosa of rats. J. Histochem. Cytochem. 41(2): 307-311, 1993.
- Pohanish, R.P. (editor): Ethyl methacrylate. Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 1117-1118.
Monitoring Methods used by OSHA
Laboratory Sampling/Analytical Method:
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sampling media: Charcoal Tube (100/50 mg sections, 20/40 mesh)
analytical solvent: Carbon Disulfide
maximum volume: 10 Liters maximum flow rate: 0.2 L/min
current analytical method: Gas Chromatography; GC/FID
method reference: OSHA Analytical Method (OSHA PV2100)
method classification: Partially Validated
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sampling media: Coated Charcoal Tube (110/55 mg sections; 20/40 mesh); Coating is 10% (w/w) 4-t-Butylcatechol.
analytical solvent: Carbon Disulfide
alternate solvent: Toluene
maximum volume: 3 Liters maximum flow rate: 0.05 L/min
current analytical method: Gas Chromatography; GC/FID
method reference: OSHA SLTC In-House File
method classification: Not Validated
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