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Chemical Sampling Information |
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| 1,2-Epoxybutane |
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General Description
Synonyms: 1,2-Butene oxide; Ethyloxirane; Butylene Oxide (Stabilized); EBU
OSHA IMIS Code Number: E225
Chemical Abstracts Service (CAS) Registry Number: 106-88-7
NIOSH, Registry of Toxic Effects (RTECS) Identification Number: EK3675000
Chemical Description and Physical Properties: Colorless liquid with characteristic odor
molecular formula: C4H8O
molecular weight: 72.12
boiling point: 63.3°C
vapor pressure: 18.8 kPa @ 20°C
melting point: -130°C
flash point: -22°C
Potentially hazardous incompatibilities: Reacts with strong oxidants causing fire hazard. Vapors mixed with air easily form explosive mixtures.
Health Factors
International Agency for Research on Cancer (IARC) carcinogenic classification: Group 2B, Possibly carcinogenic to humans
Potential symptoms: Eye, skin, respiratory tract irritation; sore throat; cough, shortness of breath, pulmonary edema; nausea; confusion, dizziness, lightheadedness, unconsciousness; blisters. INGES. ACUTE: Abdominal pain.
Health Effects: Irritation-Eyes, Nose, Throat, Skin---Marked (HE14); Nervous System Disturbances (HE7); Explosive, Flammable (HE18).
Affected organs: Eyes, skin, respiratory system, CNS
Notes:
- OSHA does not have a PEL for 1,2-epoxybutane, but it is an OSHA select carcinogen.
- Vapor/air mixtures are explosive.
- EPA's inhalation reference concentration (daily inhalation exposure likely to be without an appreciable risk of deleterious effects during a lifetime) is 0.02 mg/m3/day.
- Rats exposed 6 hours/day, 4 days/week for 5 months to 2000 ppm 1,2-epoxybutane developed mild ataxia in the hindlegs and showed axonal degeneration in the dorsal portion of the fasciculus gracillis of the spinal cord. This neuropathy, however, has not been reported for human exposure to this chemical.
Date Last Revised: 10/20/2005
Literature Basis:
- International Chemical Safety Cards (WHO/IPCS/ILO): Butylene oxide (stabilized).
- U.S. EPA Integrated Risk Information System: 1,2-Epoxybutane (CASRN 106-88-7).
- No authors: 1,2-Epoxybutane. IARC Monogr. Eval. Carcinog. Risks Hum. 71(Pt. 2): 629-640, 1999.
- Ohnishi, A. and Murai, Y.: Polyneuropathy due to ethylene oxide, propylene oxide and butylene oxide. Environ. Res. 60(2): 242-247, 1993.
- Pohanish, R.P. (editor): 1,2-Butylene Oxide. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 411-412.
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