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|Chemical Sampling Information|
OSHA IMIS Code Number: 0960
Chemical Abstracts Service (CAS) Registry Number: 77-78-1
NIOSH, Registry of Toxic Effects (RTECS) Identification Number: WS8225000
Department of Transportation Regulation Number (49 CFR 172.101) and Guide: 1595 156 [27 KB, PDF]
NIOSH Pocket Guide to Chemical Hazards, Dimethyl sulfate: chemical description, physical properties, potentially hazardous incompatibilities, and more
OSHA Permissible Exposure Limit (PEL) for Construction Industry: 29 CFR 1926.55 Appendix A -- 1 ppm, 5 mg/m3 TWA; Skin
OSHA Permissible Exposure Limit (PEL) for Maritime: 29 CFR 1915.1000 Table Z-Shipyards -- 1 ppm, 5 mg/m3 TWA; Skin
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 0.1 ppm, 0.52 mg/m3 TWA; Skin; Appendix A3 - Confirmed Animal Carcinogen with Unknown Relevance to Humans
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 0.1 ppm, 0.5 mg/m3 TWA; Skin; Appendix A - NIOSH Potential Occupational Carcinogens
International Agency for Research on Cancer (IARC) carcinogenic classification: Group 2A, Probably carcinogenic to humans [106 KB, PDF, 14 pages]
Environmental Protection Agency (EPA) carcinogenic classification: Group B2, Probable human carcinogen
NIOSH Immediately Dangerous To Life or Health Concentration (IDLH): 7 ppm
Potential symptoms: Irritation of eyes, nose; headache; dizziness; lacrimation, conjunctivitis; photophobia; periorbital edema; sore throat; hoarseness, aphonia, dysphagia, cough; chest tightness, pain; dyspnea, pulmonary edema (delayed); cyanosis; vomiting, diarrhea; dysuria; analgesia; fever; proteinuria, hematuria; skin, eye burns; blurred vision; delirium (potential occupational carcinogen); INGES ACUTE: Abdominal cramps; burning sensation; edema of lips, tongue and pharynx; convulsions; shock or collapse.
Health Effects: Mutagen (HE2); Acute eye, lung and skin effects (HE4)
Affected organs: Eyes, skin, respiratory system, liver, kidneys, CNS
Notes: 1) No odor warning if toxic concentrations are present. Lethal exposure known to be as low as 97 ppm for 10 minutes. 2) Reactions include decomposition on contact with water to methanol, methyl hydrogen sulfate and sulfuric acid; and methylation of DNA and some proteins. 3) Blood N-methylvaline levels have been used to study occupational exposure to dimethyl sulfate and suggest skin as the major site of absorption.
Date Last Revised: 03/10/2004
On-Site Sampling Techniques/Methods:
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