Chemical Sampling Information
	Dimethylphthalate
Quick Links General Description Exposure Limits Health Factors Monitoring Search    [use word(s)/phrase] Table of Contents By Name A B C D E F G H I J K L M N O P Q R S T U V W X Y Z By CAS Number General Description Synonyms: DMP; Dimethyl 1,2-benzenedicarboxylate; Dimethyl ester of 1,2-benzenedicarboxylic acid; Dimethyl phthalate; Phthalic acid, dimethyl ester OSHA IMIS Code Number: 0950 Chemical Abstracts Service (CAS) Registry Number: 131-11-3 NIOSH, Registry of Toxic Effects (RTECS) Identification Number: TI1575000 NIOSH Pocket Guide to Chemical Hazards, Dimethylphthalate: chemical description, physical properties, potentially hazardous incompatibilities, and more Exposure Limits OSHA Permissible Exposure Limit (PEL) for General Industry: 29 CFR 1910.1000 Z-1 Table -- 5 mg/m3 TWA OSHA Permissible Exposure Limit (PEL) for Construction Industry: 29 CFR 1926.55 Appendix A -- 5 mg/m3 TWA OSHA Permissible Exposure Limit (PEL) for Maritime: 29 CFR 1915.1000 Table Z-Shipyards -- 5 mg/m3 TWA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 5 mg/m3 TWA National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 5 mg/m3 TWA Health Factors Environmental Protection Agency (EPA) carcinogenic classification: Group D, not classifiable as to human carcinogenicity NIOSH Immediately Dangerous To Life or Health Concentration (IDLH): 2,000 mg/m3 Potential symptoms: Irritation of eyes, upper respiratory system; stomach pain; dizziness, disorientation, loss of coordination; INGES. ACUTE: Vomiting, diarrhea, unconsciousness. Health Effects: Irritation-Eyes, Nose, Throat---Mild (HE16) Affected organs: Eyes, respiratory system, GI tract Notes: A rat 24-hour urine collection following the administration of 0.1 ml of dimethyl phthalate by oral gavage contained 8.1% parent compound; 77.5% of the total excreted phthalate was monomethyl phthalate, and 14.4% was phthalic acid. A NOAEL for maternal toxicity of 1% was reported for pregnant rats administered 0.25, 1 or 5% dimethyl phthalate in the diet during gestational days 6-15, and no effect of dimethyl phthalate feeding was observed on any parameter of embryo/fetal development. The steady state absorption rate of dimethyl phthalate (3.95 ± 0.64 µg/cm2/hr) through human skin was reported to be less than 10% the rate through rat skin in vitro. Date Last Revised: 05/15/2007 Literature Basis: NIOSH Pocket Guide to Chemical Hazards: Dimethylphthalate. International Chemical Safety Cards (WHO/IPCS/ILO): Dimethyl phthalate. EPA Air Toxics Website: Dimethyl Phthalate. U.S. Environmental Protection Agency Technology Transfer Network. Albro, P.W. and Moore, B.: Identification of the metabolites of simple phthalate diesters in rat urine. J. Chromatogr. 94(0): 209-218, 1974. Field, E.A., et al.: Developmental toxicity evaluation of diethyl and dimethyl phthalate in rats. Teratology 48(1): 33-44, 1993. Pohanish, R.P. (editor): Dimethyl Phthalate. In, Sittig’s Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 936-939. Scott, R.C., Dugard, P.H., Ramsey, J.D. and Rhodes, C.: In vitro absorption of some o-phthalate diesters through human and rat skin. Environ. Health Perspect. 74: 223-227, 1987. Monitoring Methods used by OSHA Laboratory Sampling/Analytical Method: sampling media: OSHA Versatile Sampler (OVS-Tenax) - 13 mm Tenax Tube (140/70 mg sections) with a Glass Fiber filter enclosed analytical solvent: Toluene maximum volume: 240 Liters   maximum flow rate: 1.0 L/min current analytical method: Gas Chromatography; GC/FID method reference: OSHA Analytical Method (OSHA 104) method classification: Fully Validated All Trademarks are the property of their respective owners. Accessibility Assistance: Contact the OSHA Directorate of Science, Technology and Medicine at 202-693-2300 for assistance accessing PDF materials.