NIOSH Immediately Dangerous To Life or Health Concentration (IDLH):2,000 mg/m3
Potential symptoms: Irritation of eyes, upper respiratory system; stomach pain; dizziness, disorientation, loss of coordination; INGES. ACUTE: Vomiting, diarrhea, unconsciousness.
Health Effects: Irritation-Eyes, Nose, Throat---Mild (HE16)
Affected organs: Eyes, respiratory system, GI tract
A rat 24-hour urine collection following the administration of 0.1 ml of dimethyl phthalate by oral gavage contained 8.1% parent compound; 77.5% of the total excreted phthalate was monomethyl phthalate, and 14.4% was phthalic acid.
A NOAEL for maternal toxicity of 1% was reported for pregnant rats administered 0.25, 1 or 5% dimethyl phthalate in the diet during gestational days 6-15, and no effect of dimethyl phthalate feeding was observed on any parameter of embryo/fetal development.
The steady state absorption rate of dimethyl phthalate (3.95 ± 0.64 µg/cm2/hr) through human skin was reported to be less than 10% the rate through rat skin in vitro.
EPA Air Toxics Website: Dimethyl Phthalate. U.S. Environmental Protection Agency Technology Transfer Network.
Albro, P.W. and Moore, B.: Identification of the metabolites of simple phthalate diesters in rat urine. J. Chromatogr.94(0): 209-218, 1974.
Field, E.A., et al.: Developmental toxicity evaluation of diethyl and dimethyl phthalate in rats. Teratology48(1): 33-44, 1993.
Pohanish, R.P. (editor): Dimethyl Phthalate. In, Sittig’s Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 936-939.
Scott, R.C., Dugard, P.H., Ramsey, J.D. and Rhodes, C.: In vitro absorption of some o-phthalate diesters through human and rat skin. Environ. Health Perspect.74: 223-227, 1987.