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Synonyms: Acetic acid dimethylamide; Dimethylacetamide; N,N-Dimethyl acetamide; DMAC
OSHA IMIS Code Number: 0927
Chemical Abstracts Service (CAS) Registry Number: 127-19-5
NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: AB7700000
NIOSH Pocket Guide to Chemical Hazards, Dimethyl acetamide: chemical description, physical properties, potentially hazardous incompatibilities, and more.
OSHA Permissible Exposure Limit (PEL):
General Industry: 29 CFR 1910.1000 Z-1 Table -- 10 ppm, 35 mg/m3 TWA; Skin
Construction Industry: 29 CFR 1926.55 Appendix A -- 10 ppm, 35 mg/m3 TWA; Skin
Maritime: 29 CFR 1915.1000 Table Z-Shipyards -- 10 ppm, 35 mg/m3 TWA; Skin
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 10 ppm, 36 mg/m3 TWA; Skin; Appendix A4 - Not Classifiable as a Human Carcinogen; BEI (TLV listed under N,N-Dimethylacetamide)
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL):10 ppm, 35 mg/m3 TWA; Skin
NIOSH Immediately Dangerous To Life or Health Concentration (IDLH): 300 ppm
Potential Symptoms: Irritation of skin; headache, nausea, vomiting; jaundice, liver damage; depression, drowsiness, hallucinations, delusions; INGES. ACUTE: Abdominal cramps, diarrhea; SKIN ABS
Health Effects: Cumulative liver damage (HE3); Suspect teratogen (HE5); CNS effects (HE7); Irritation-Eyes, Skin---Mild (HE16)
Affected Organs: Skin, liver, CNS
- Explosive vapor/air mixtures of dimethyl acetamide may be formed above 70°C.
- Developmental toxicity studies of dimethyl acetamide by inhalation exposure in rats reported a NOAEL of 100 ppm for both maternal toxicity (hepatocellular swelling) and fetal toxicity (fused bones and life-threatening cardiovascular malformations) that were observed at higher concentrations.
- Dermal absorption of dimethylacetamide vapor was extensive in 12 volunteers exposed (90% naked) in a chamber to 6.1 ppm for 4 hours, ranging from 13% to 73% of the total absorbed dose (mean, 40%).
- N-methylacetamide in urine (adjusted for creatinine) is measured at the end of a shift for biomonitoring N,N-dimethylacetamide exposure. Mean biological half-lives after dermal and respiratory exposure were estimated to be 9.0 and 5.6 hours, respectively.
- The incidence rate ratio for liver injury among elastane fiber employees exposed to dimethylacetamide was reported to be 9.6 for those with urinary N-methylacetamide levels >20 mg/g creatinine compared with those having levels <20 mg/g creatinine during exposure monitoring.
- Dermal absorption of dimethylacetamide is decreased by showering and changing clothing at the end of a work shift.
Date Last Revised: 04/23/2007
- NIOSH Pocket Guide to Chemical Hazards: Dimethyl acetamide.
- International Chemical Safety Cards (WHO/IPCS/ILO): N,N-Dimethylacetamide.
- Lee, C.-Y., Jung, S.-J., Kim, S.-A., Park, K.-S. and Ha, B.-G. Incidence of dimethylacetamide induced hepatic injury among new employees in a cohort of elastane fibre workers. Occup. Environ. Med. 63(10): 688-693, 2006.
- Nimiyama, T., et al. Dermal absorption of N,N-dimethylacetamide in human volunteers. Int. Arch. Occup. Environ. Health 73(2): 121-126, 2000.
- Okuda, H., et al. Developmental toxicity induced by inhalation exposure of pregnant rats to N,N-dimethylacetamide. J. Occup. Health 48(3): 154-160, 2006.
- Perbellini, L., Princivalle, A., Caivano, M. and Montagnani, R. Biological monitoring of occupational exposure to N,N-dimethylacetamide with identification of a new metabolite. Occup. Environ. Med. 60(1): 746-751.
- Pohanish, R.P. (editor) N,N-Dimethylacetamide. In Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 905-907.
Laboratory Sampling/Analytical Method:
- sampling media: Silica Gel Tube (150/75 mg sections, 20/40 mesh)
analytical solvent: Methanol
maximum volume: 80 Liters
maximum flow rate: 1.0 L/min )
current analytical method: Gas Chromatography; GC/FID
method reference: NIOSH Analytical Method (NIOSH 2004) [27 KB PDF, 5 pages]
method classification: Fully Validated
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