Chemical Sampling Information
	Diethyl phthalate
Quick Links General Description Exposure Limits Health Factors Monitoring Search    [use word(s)/phrase] Table of Contents By Name A B C D E F G H I J K L M N O P Q R S T U V W X Y Z By CAS Number General Description Synonyms: 1,2-Benzenedicarboxylic acid diethyl ester; DEP; Diethyl ester of phthalic acid; Ethyl phthalate; Phthalic acid, diethyl ester OSHA IMIS Code Number: 0933 Chemical Abstracts Service (CAS) Registry Number: 84-66-2 NIOSH, Registry of Toxic Effects (RTECS) Identification Number: TI1050000 NIOSH Pocket Guide to Chemical Hazards, Diethyl phthalate: chemical description, physical properties, potentially hazardous incompatibilities, and more Exposure Limits American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 5 mg/m3 TWA; Appendix A4 - Not Classifiable as a Human Carcinogen National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 5 mg/m3 TWA Health Factors Environmental Protection Agency (EPA) carcinogenic classification: Group D, not classifiable as to human carcinogenicity Potential symptoms: Irritation of eyes, skin, nose, throat; headache, dizziness, nausea; lacrimation; possible polyneuropathy, vestibular dysfunction; pain, numbness, lassitude, spasms in arms and legs; in animals: reproductive effects; INGES. ACUTE: Abdominal pain, nausea. Health Effects: Irritation-Eyes, Nose, Throat---Mild (HE16) Affected organs: Eyes, skin, respiratory system, CNS, peripheral nervous system, reproductive system Notes: OSHA does not have a PEL for diethyl phthalate. EPA’s oral reference dose (daily oral exposure likely to be without an appreciable risk of deleterious non-cancer effects during a lifetime) of diethyl phthalate is 0.8 mg/kg/day. Diethyl phthalate is regulated as a denaturant for alcohol (27 CFR 21.106) and it is often used at a concentration of 0.5% to denature ethanol used in cosmetic products. Although several cases of allergy to diethyl phthalate have been reported, attempts to sensitize skin in studies with animals and human volunteers have not been successful. In a randomly selected adult reference U.S. population, the urinary metabolite monoethyl phthalate (median, 305 µg/L) occurred in much greater concentrations than the metabolites of six other phthalate derivatives. The absorption rate of diethyl phthalate was reported to be much slower through human skin than through rat skin in vitro. Date Last Revised: 05/14/2007 Literature Basis: NIOSH Pocket Guide to Chemical Hazards: Diethyl phthalate. International Chemical Safety Cards (WHO/IPCS/ILO): Diethyl phthalate. U.S. EPA Integrated Risk Information System: Diethyl phthalate (CASRN 84-66-2). Api, A.M.: Toxicological profile of diethyl phthalate: a vehicle for fragrance and cosmetic ingredients. Food Chem. Toxicol. 39(2): 97-108, 2001. Blount, B.C., et al.: Levels of seven urinary phthalate metabolites in a human reference population. Environ. Health Perspect. 108(10): 979-982, 2000. David, R.M., Lockhart, L.K. and Ruble, K.L.: Lack of sensitization for trimellitate, phthalate, terephthlate and isobutyrate plasticizers in a human repeated insult patch test. Food Chem. Toxicol. 41(4): 589-593, 2003. Pohanish, R.P. (editor): Diethyl Phthalate. In, Sittig’s Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 880-882. Scott, R.C., Dugard, P.H., Ramsey, J.D. and Rhodes, C.: In vitro absorption of some o-phthalate diesters through human and rat skin. Environ. Health Perspect. 74: 223-227, 1987. Monitoring Methods used by OSHA Laboratory Sampling/Analytical Method: sampling media: OSHA Versatile Sampler (OVS-Tenax) - 13 mm Tenax Tube (140/70 mg sections) with a Glass Fiber filter enclosed analytical solvent: Toluene maximum volume: 240 Liters   maximum flow rate: 1.0 L/min current analytical method: Gas Chromatography; GC/FID method reference: OSHA Analytical Method (OSHA 104) method classification: Fully Validated All Trademarks are the property of their respective owners.