||Safety and Health Topics:
Synonyms: 2,2'-Iminobisethanol; 2,2'-Iminodiethanol; Diethylolamine; Bis(2-hydroxyethyl)amine; 2,2'-Dihydroxydiethylamine; DEA
OSHA IMIS Code Number: D129
Chemical Abstracts Service (CAS) Registry Number: 111-42-2
NIOSH, Registry of Toxic Effects (RTECS) Identification Number: KL2975000
NIOSH Pocket Guide to Chemical Hazards, Diethanolamine: chemical description, physical properties, potentially hazardous incompatibilities, and more
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 0.46 ppm, 2 mg/m3 TWA; Skin
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 3 ppm, 15 mg/m3 TWA
Potential symptoms: Irritation of eyes, skin, nose, throat; lacrimation, eye burns, corneal necrosis; skin burns; sneezing, coughing, wheezing, shortness of breath; headache; nausea, vomiting; INGES ACUTE: abdominal pain, burning sensation.
Monitoring Methods used by OSHA
Health Effects: Irritation-Eyes, Skin, Nose, Throat---Marked (HE14); Cumulative Toxicity---Liver carcinogen in mice (HE2).
Affected organs: Eyes, skin, respiratory system
Notes: 1) Although a connection between diethanolamine in metal working fluids and and increased risk of stomach cancer has been postulated, the only type of cancer caused by 2-year skin-application studies in rodents was liver cancer in mice. 2) One case of diethanolamine-induced occupational asthma has been reported. 3) Animal studies show slow excretion in the urine and accumulation in liver, kidney, spleen, and brain, where it may be metabolized into aberrant phospholipids.
Date Last Revised: 02/09/2004
- EPA Air Toxics Website: Diethanolamine. U.S. Environmental Protection Agency Technology Transfer Network.
- NIOSH Pocket Guide to Chemical Hazards: Diethanolamine.
- International Chemical Safety Cards (WHO/IPCS/ILO): Diethanolamine.
- Mathews, J.M., Garner, C.E. and Matthews, H.B.: Metabolism, bioaccumulation, and incorporation of diethanolamine into phospholipids. Chem. Res. Toxicol. 8(5): 625-633, 1995.
- Mirer, F.: Updated epidemiology of workers exposed to metalworking fluids provides sufficient evidence for carcinogenicity. Appl. Occup. Environ. Hyg. 18(11):902-912, 2003.
- National Toxicology Program: NTP Toxicology and carcinogenesis studies of diethanolamine (CAS No. 111-42-2) in F344/N rats and B6C3F1 mice (dermal studies). Natl. Toxicol. Program Tech. Rep. Ser. 478: 1-212, 1999.
- Piipari, R., et al.: Diethanolamine-induced occupational asthma, a case report. Clin. Exp. Allergy 28(3): 358-362, 1998.
- Pohanish, R.P. (editor): Diethanolamine. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 860-862.
Laboratory Sampling/Analytical Method:
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sampling media: Coated XAD-2 Tube (80/40 mg sections, 20/60 mesh); Coating is 10% (w/w) 1-Naphthylisothiocyanate (NITC)
analytical solvent: Dimethylformamide
maximum volume: 10 Liters maximum flow rate: 0.1 L/min
current analytical method: High Performance Liquid chromatography; HPLC/UV
method reference: OSHA Analytical Method (OSHA PV2018)
method classification: Partially Validated
note: OSHA personnel may obtain sampling tubes from SLTC.