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Chemical Sampling Information |
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| Diazinon® |
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General Description
Synonyms: O,O-Diethyl O-(2-isopropyl-4-methyl-6-pyrimidinyl)- phosphorthioate; Spectracide; Phosphorothioic acid, O,O-diethyl O-(2-isopropyl-6-methyl-4-pyrimidinyl) ester
OSHA IMIS Code Number: 2720
Chemical Abstracts Service (CAS) Registry Number: 333-41-5
NIOSH, Registry of Toxic Effects (RTECS) Identification Number: TF3325000
Department of Transportation Regulation Number (49 CFR 172.101) and Guide: 2783 152
NIOSH Pocket Guide to Chemical Hazards, Diazinon®: chemical description, physical properties, potentially hazardous incompatibilities, and more
Exposure Limits
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 0.1 mg/m3 TWA - Inhalable fraction and vapor; Skin; Appendix A4 - Not Classifiable as a Human Carcinogen; BEIA: see BEI® for Acetylcholinesterase Inhibiting Pesticides
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 0.1 mg/m3 TWA; Skin
Health Factors
Potential symptoms: Eye irritation, miosis, blurred vision; headache, dizziness, confusion, lassitude (weakness, exhaustion); convulsions; dyspnea (breathing difficulty); excessive salivation, sweating; abdominal cramps, nausea, vomiting, diarrhea; unconsciousness.
Health Effects: Cholinesterase inhibition (HE6); Suspect teratogen (HE5); Mutagen (HE2)
Affected organs: Eyes, respiratory system, CNS, cardiovascular system, blood cholinesterase
Notes:
- OSHA does not have a PEL for diazinon.
- Diazinon® is activated to the cholinesterase inhibitor diazoxon predominantly by cytochrome P450 2C19.
- Biomarkers of exposure include measurement of cholinesterase activity in blood plasma and in red blood cells and urinary dialkyl phosphate metabolites.
- Urinary metabolites include diethyl phosphate and diethyl thiophosphate. which have an elimination half-life in urine of approximately two hours in human volunteers following oral administration of diazinon (11 µg/kg body weight) and an elimination half-life of about nine hours after dermal application of 100 mg.
Date Last Revised: 07/01/2005
Literature Basis:
- NIOSH Pocket Guide to Chemical Hazards: Diazinon®.
- International Chemical Safety Cards (WHO/IPCS/ILO): Diazinon.
- Garfitt, S.J., Jones, K., Mason, H.J. and Cocker, J.: Exposure to the organophosphate diazinon: data from a human volunteer study with oral and dermal doses. Toxicol. Lett. 134(1-3): 105-113, 2002.
- Kappers, W.A., Edwards, R.J., Murray, S. and Boobis, A.R.: Diazinon® is activated by CYP2C19 in human liver. Toxicol. Appl. Pharmacol. 177(1): 68-76, 2001.
- Pohanish, R.P. (editor): Diazinon®. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 770-772.
Monitoring Methods used by OSHA
Laboratory Sampling/Analytical Method:
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sampling media: OSHA Versatile Sampler (OVS-2) - 13 mm XAD-2 tube (270/140 mg sections, 20/60 mesh) with Glass Fiber Filter enclosed
maximum volume: 480 Liters maximum flow rate: 1.0 L/min
current analytical method: Gas Chromatography; GC/FPD
method reference: OSHA Analytical Method (OSHA 62)
method classification: Fully Validated
note: OSHA personnel may obtain sampling tubes from SLTC.
Bulk method: Limit the amount of bulk submitted to one gram or one mL.
* All Trademarks are the property of their respective owners.
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