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Chemical Sampling Information |
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| Cyclohexanone |
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General Description
Synonyms: Anone; Pimelic ketone; Cyclohexyl ketone; Ketohexamethylene
OSHA IMIS Code Number: 0830
Chemical Abstracts Service (CAS) Registry Number: 108-94-1
NIOSH, Registry of Toxic Effects (RTECS) Identification Number: GW1050000
Department of Transportation Regulation Number (49 CFR 172.101) and Guide: 1915 127
NIOSH Pocket Guide to Chemical Hazards, Cyclohexanone: chemical description, physical properties, potentially hazardous incompatibilities, and more
Exposure Limits
OSHA Permissible Exposure Limit (PEL) for General Industry: 29 CFR 1910.1000 Z-1 Table -- 50 ppm, 200 mg/m3 TWA
OSHA Permissible Exposure Limit (PEL) for Construction Industry: 29 CFR 1926.55 Appendix A -- 50 ppm, 200 mg/m3 TWA
OSHA Permissible Exposure Limit (PEL) for Maritime: 29 CFR 1915.1000 Table Z-Shipyards -- 50 ppm, 200 mg/m3 TWA
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 20 ppm, 80 mg/m3 TWA; 50 ppm, 200 mg/m3 STEL; Skin; Appendix A3 - Confirmed Animal Carcinogen with Unknown Relevance to Humans
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 25 ppm, 100 mg/m3 TWA; Skin
Health Factors
NIOSH Immediately Dangerous To Life or Health Concentration (IDLH): 700 ppm
Potential symptoms: Irritation of eyes, skin, mucous membrane; headache; narcosis; coma; dermatitis; in animals: liver, kidney damage
Health Effects: Irritation-Eye, Nose, Throat, Skin---Moderate (HE15); Cumulative liver and kidney damage (HE3); Narcosis (HE8)
Affected organs: Eyes, skin, respiratory system, CNS, liver, kidneys
Notes:
- Above 44ºC, explosive vapor/air mixtures may be formed.
- EPA’s oral reference dose (daily oral exposure likely to be without an appreciable risk of deleterious effects during a lifetime) for cyclohexanone is 5 mg/kg/day.
- Two cases of contact dermatitis due to cyclohexanone exposure have been reported.
- In a study with human volunteers who inhaled cyclohexanone for 8 hours, the major urinary metabolites over 72 hours were found to be 1,2-cyclohexanediol (38-41% of dose) and 1,4-cyclohexanediol (18-21% of dose), including their glucuronide conjugates. These metabolites appeared to be useful for biomonitoring exposure to cyclohexanone.
Date Last Revised: 05/05/2006
Literature Basis:
- NIOSH Pocket Guide to Chemical Hazards: Cyclohexanone.
- International Chemical Safety Cards (WHO/IPCS/ILO): Cyclohexanone.
- U.S. EPA Integrated Risk Information System: Cyclohexanone (CASRN 108-94-1).
- Mráz, J., Gálová, E., Nohová, H. and Vítková, D.: Uptake, metabolism and elimination of cyclohexanone in humans. Int. Arch. Occup. Environ. Health 66(3): 203-208, 1994.
- Pazzaglio, M., Tullo, S., Voudouris, S. and Tosti, A.: Contact dermatitis due to cyclohexanone: a further case. Contact Dermatitis 49(6): 313, 2003.
- Pohanish, R.P. (editor): Cyclohexanone. In, Sittig’s Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 719-721.
Monitoring Methods used by OSHA
Laboratory Sampling/Analytical Method:
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sampling media: Chromosorb 106 Tube (100/50 sections, 60/80 mesh)
analytical solvent: Carbon Disulfide
maximum volume: 10 Liters maximum flow rate: 0.2 L/min
current analytical method: Gas Chromatography; GC/FID
method reference: OSHA Analytical Method (OSHA 1)
method classification: Fully Validated
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