<< Back to Chemical Sampling Information
Synonyms: 2-Chloro-1,3-butadiene; Chlorobutadiene; Chloroprene
OSHA IMIS Code Number: 0680
IMIS Name History: Chloroprene prior to 5/30/07
Chemical Abstracts Service (CAS) Registry Number: 126-99-8
NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: EI9625000
Department of Transportation Regulation Number (49 CFR 172.101) and Guide: 1991 131P (inhibited)
NIOSH Pocket Guide to Chemical Hazards, beta-Chloroprene: chemical description, physical properties, potentially hazardous incompatibilities, and more
OSHA Permissible Exposure Limit (PEL):
General Industry: 29 CFR 1910.1000 Z-1 Table -- 25 ppm, 90 mg/m3 TWA; Skin
Construction Industry: 29 CFR 1926.55 Appendix A -- 25 ppm, 90 mg/m3 TWA; Skin
Maritime: 29 CFR 1915.1000 Table Z-Shipyards -- 25 ppm, 90 mg/m3 TWA; Skin
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 10 ppm, 36 mg/m3 TWA; Skin
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 1 ppm, 3.6 mg/m3 Ceiling (15 minutes); Appendix A - NIOSH Potential Occupational Carcinogens
Environmental Protection Agency (EPA): Group D, not classifiable as to human carcinogenicity
International Agency for Research on Cancer (IARC): Group 2B, possibly carcinogenic to humans (beta-Chloroprene) [381 KB PDF, 171 pages]
National Toxicology Program (NTP): Reasonably anticipated to be human carcinogen [104 KB PDF, 3 pages]
NIOSH Immediately Dangerous To Life or Health Concentration (IDLH): 300 ppm
Potential Symptoms: Irritation of eyes, skin, respiratory system; cough, sore throat; headache, dizziness, drowsiness, anxiety, irritability; dermatitis, alopecia; reproductive effects; SKIN ABS.: redness, pain; [potential occupational carcinogen]
Health Effects: Reproductive Hazard (HE5); Systemic Toxicity (HE3); Suspected human carcinogen, mutagen (HE2).
Affected Organs: Eyes, skin, respiratory system, reproductive system
- Chloroprene is an OSHA Select Carcinogen.
- EPA’s inhalation reference concentration (daily inhalational exposure likely to be without an appreciable risk of deleterious effects during a lifetime) for chloroprene is 7 µg/m3, and EPA’s provisional reference dose (RfD) for chloroprene is 0.02 mg/kg/day.
- Chloroprene is metabolized by cytochrome P-450 2E1 to reactive epoxide intermediates, including enantiomers of (1-chloroethenyl)oxirane, which can form adducts with glutathione, hemoglobin, and DNA. No reports of using any of these adducts as markers for occupational exposure to chloroprene were found.
- Anemia has been reported to occur in Fischer 344 rats exposed subchronically to 200 ppm chloroprene, as well as in employees occupationally exposed to unreported levels of chloroprene.
Date Last Revised: 08/25/2006
- NIOSH Pocket Guide to Chemical Hazards: beta-Chloroprene.
- International Chemical Safety Cards (WHO/IPCS/ILO): Chloroprene.
- EPA Technology Transfer Network Air Toxics Website: Chloroprene (2-Chloro-1,3-Butadiene).
- Hurst, H.E. and Ali, M.Y.: Analyses of (1-chloroethenyl)oxirane headspace and hemoglobin N-valine adducts in erythrocytes indicate selective detoxification of (1-chloroethenyl)oxirane enantiomers. Chem. Biol. Interact. 166(1-3): 332-340, 2007.
- Munter, T., Cottrell, L., Ghai, R., Golding, B.T. and Watson, W.P.: The metabolism and molecular toxicology of chloroprene. Chem. Biol. Interact. 166(1-3): 323-331, 2007.
- No Author: Chloroprene [104 KB PDF, 3 pages]. Report on Carcinogens (latest edition); U.S. Department of Health and Human Services, Public Health Service, National Toxicology Program.
- Pohanish, R.P. (editor): Chloroprene. In, Sittig’s Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 591-593.
- Sanotskii, I.V.: Aspects of the toxicology of chloroprene: immediate and long-term effects. Environ. Health Perspect. 17: 85-93, 1976.
- Valentine, R. and Himmelstein, M.W.: Overview of the acute, subchronic, reproductive, developmental and genetic toxicology of beta-chloroprene. Chem. Biol. Interact. 135-136: 81-100, 2001.
Primary Laboratory Sampling/Analytical Method (SLC1):
- sampling media: Chromosorb 106 (600/300 mg sections, 60/80 mesh)
analytical solvent: Toluene
maximum volume: 6 Liters
maximum flow rate: 0.05 L/min
current analytical method: Gas Chromatography; GC/ECD
method reference: OSHA Analytical Method (OSHA 112)
method classification: Fully Validated
Wipe Sampling Method:
** All Trademarks are the property of their respective owners.
sampling media: charcoal pad
note: Seal in glass vial for shipment.