||Chemical Sampling Information
Synonyms: 3-Hydroxybutanoic Acid, beta-Lactone; Hydroxybutyric Acid Lactone; 3-Hydroxybutyric Acid, beta-Lactone; 4-Methyl-2-Oxetanone
OSHA IMIS Code Number: B427
Chemical Abstracts Service (CAS) Registry Number: 3068-88-0
NIOSH, Registry of Toxic Effects (RTECS) Identification Number: RQ8050000
Chemical Description and Physical Properties: liquid
molecular formula: C4H6O2
molecular weight: 86.09
boiling point: 71-73°C
flash point: 60°C
melting point: -43.5°C
International Agency for Research on Cancer (IARC) carcinogenic classification: Group 2B, possibly carcinogenic to humans [381 KB, PDF]
Potential symptoms: No symptoms for this chemical are available.
Health Effects: Known animal carcinogen (HE2); LD50 (oral, rat) is 17 ml/kg.
Affected organs: Skin (where applied in animal carcinogenicity studies)
- OSHA does not have a PEL for ß-butyrolactone.
- ß-Butyrolactone can form adducts with the nucleosides, guanosine, adenosine and cytidine. Adduct formation with DNA and RNA have also been demonstrated.
- ß-Butyrolactone is metabolized to 2-hydroxybutyric acid by carboxylesterases in animal tissues from nasal turbinates, trachea, lungs and liver, with specific tissue activity decreasing in the order, rabbit > hamster > rat.
Date Last Revised: 05/24/2007
Monitoring Methods used by OSHA
- Dahl, A.R., Miller, S.C. and Petridou-Fischer, J.: Carboxylesterases in the respiratory tracts of rabbits, rats and Syrian hamsters. Toxicol. Lett. 36(2): 129-136, 1987.
- Hemminki, K.: Reactions of beta-propiolactone, beta-butyrolactone and gamma-butyrolactone with nucleic acids. Chem. Biol. Interact. 34(3): 323-331, 1981.
- No authors listed: beta-Butyrolactone. IARC Monogr. Eval. Carcinog. Risks Hum. 71(Pt. 3): 1317-1318, 1999. [381 KB, PDF]
- Smyth, H.F., Jr., Carpenter, C.P., Weil, C.S., Pozzani, U.C., Striegel, J.A. and Nycum, J.S.: Range-finding toxicity data: List VII. Am. Ind. Hyg. Assoc. J. 30(5): 470-476, 1969.
Laboratory Sampling/Analytical Method:
sampling media: Charcoal Tube (100/50 mg sections, 20/40 mesh)
analytical solvent: (95:5) Methylene Chloride:Methanol
maximum volume: 10 Liters maximum flow rate: 1 L/min
current analytical method: Gas Chromatography; GC/FID
method reference: OSHA SLTC In-House File
method classification: Not Validated
analytical condition: Samples were received requesting cellosolves and butyrolactone. Phase equilibrium studies looked reasonable and gama-butyrolactone was found and confirmed on the "A" portion of a sample.
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