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Synonyms: Isopropyl bromide
OSHA IMIS Code Number: R289
Chemical Abstracts Service (CAS) Registry Number: 75-26-3
NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: TX4111000
Department of Transportation Regulation Number (49 CFR 172.101) and Guide: 2344 129
Chemical Description and Physical Properties:
clear, colorless to slightly yellow flammable liquid
molecular weight: 123.01
vapor pressure: 31.5 kPa @ 25°C
molecular formula: C3H7Br
boiling point: 59.0°C
melting point: -89°C
22°C closed cup
Potential Symptoms: Eye, skin irritation; dizziness, lightheadedness, unconsciousness; anemia, amenorrhea (in females); oligospermia, azospermia (in males).
Health Effects: Irritation-Eye Nose, Throat, Skin---Mild (HE16); Reproductive impairment (HE5); Hematologic disturbances (HE12); Narcosis (HE8).
Affected Organs: Eyes, skin, reproductive system, CNS
- OSHA does not have a PEL for 2-bromopropane. South Korea recommended an occupational exposure level of 1 ppm as a TWA on the basis of occupational studies in South Korea, China and Japan.
- The two major urinary metabolites of 2-bromopropane, acetone and bromide ion, are normal constituents of urine and might not be useful for monitoring low levels of occupational exposure.
- NTP's Center for the Evaluation of Risks to Human Reproduction has expressed some concern for adverse reproductive effects (e.g., decreased sperm count and motility; amenorrhea) at the upper end of reported human occupational exposures in the U.S. to 2-bromopropane (<0.004 to 1.35 ppm), which occur secondarily to its contamination of 1-bromopropane. In other countries where 2-bromopropane is used directly, occupational exposures at higher levels have been reported up to110.8 ppm in breathing zone samples and 16.18 ppm (8-hour TWA) in personal air samples.
- National Toxicology Program: NTP-CERHR Monograph on the Potential Human Reproductive and Developmental Effects of 2-Bromopropane (2-BP) [784 KB PDF, 71 pages].
- Ichihara, G.: Neuro-reproductive toxicities of 1-bromopropane and 2-bromopropane. Int. Arch. Occup. Environ. Med. 78(2): 79-96, 2005.
- Ichihara, G., et al.: Occupational health survey on workers exposed to 2-bromopropane at low concentrations. Am. J. Ind. Med. 35(5): 523-531, 1999.
- Park, J.-S., Kim, Y., Park, D.W., Choi, K.S. Park, S.-H. and Moon, Y.-H.: An outbreak of hematopoietic and preproductive disorders due to solvents containing 2-bromopropane in an electronic factory, South Korea: Epidemiological survey. J. Occup. Health 39(2): 138-143, 1997.
- Pohanish, R.P. (editor): Bromopropane. In, Sittig’s Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 380-381.
- Yu, I.J., Kim, H.Y., Lim, C.H., Lee, Y.M. and Moon, Y.H.: The occupational exposure level (OEL) for 2-bromopropane: the first OEL established by Korea. Appl. Occup. Environ. Hyg. 14(6): 356-358, 1999.
Date Last Revised: 06/12/2007
Primary Laboratory Sampling/Analytical Method (SLC1):
- sampling media: Coconut shell charcoal (CSC) tube (6-mm o.d., 100/50-mg sections)
analytical solvent: (99:1) Carbon disulfide (CS2):Dimethylformide (DMF)
maximum volume: 12 Liters
maximum flow rate: 0.1 L/min
maximum time: 120 Minutes
current analytical method: Gas chromatography; GC/FID
method reference: OSHA Analytical Method (OSHA PV2062)
method classification: Partially Validated
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