Chemical Sampling Information
	3-Aminopyridine
Quick Links General Description Health Factors Monitoring Search    [use word(s)/phrase ] Table of Contents By Name A B C D E F G H I J K L M N O P Q R S T U V W X Y Z By CAS Number General Description Synonyms: ß-aminopyridine; 3-AP; 3-pyridylamine m-aminopyridine; amino-3-pyridine; ß-pyridylamine OSHA IMIS Code Number: A174 Chemical Abstracts Service (CAS) Registry Number: 462-08-8 Chemical Description and Physical Properties: white to light yellow-brown crystals with characteristic unpleasant odor molecular formula: C5H6N2 molecular weight: 94.13 boiling point: 251°C (484°F) flash point: 88°C (190°F) (closed cup) solubility: soluble in water, alcohol, ether melting point: 64°C (147°F) Health Factors Potential symptoms: Irritation of eyes (redness, pain), skin (redness, pain), respiratory tract, and digestive tract; headache, nausea, increased blood pressure, weakness; tremor, excitability, convulsions, stupor. Health Effects: Poisonous (HE4); Convulsions (HE7); Irritation-Eyes, Nose, Throat, Skin---Marked (HE14) Affected organs: CNS, eyes, skin Notes: OSHA does not have a PEL for 3-aminopyridine, which may be fatal if absorbed through the skin or swallowed. 3-Aminopyridine is a potassium channel blocker used as a research tool to induce seizures in experimental animal models of epilepsy. Date Last Revised: 09/19/2006 Literature Basis: Acros Organics N.V.: Material Safety Data Sheet: 3-Aminopyridine, 99%. Galvan, M., Franz, P. and Vogel-Weins, C.: Actions of potassium channel blockers on guinea-pig lateral olfactory tract axons. Naunyn-Schmiedebergs Arch. Pharmacol. 325(1): 8-11, 1984. Riker, W.K., Matsumoto, M. and Takashima, K.: Synaptic facilitation by 3-aminopyridine and its antagonism by verapamil and diltiazem. J. Pharmacol. Exp. Ther. 235(2): 431-435, 1985. Slezia, A., et al.: Uridine release during aminopyridine-induced epilepsy. Neurobiol. Dis. 16(3): 490-499, 2004. Monitoring Methods used by OSHA Laboratory Sampling/Analytical Method: sampling media: three-piece cassettes containing two sulfuric acid-treated glass fiber filters separated by a spacer in a closed face cassette analytical solvent: 0.1 N NaOH maximum volume: 240 Liters   maximum flow rate: 1.0 L/min current analytical method: Gas Chromatography; GC/NPD method reference: OSHA Analytical Method (OSHA PV2143) method classification: Partially Validated All Trademarks are the property of their respective owners.