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Chemical Sampling Information (CSI)
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General Description

Synonyms: ß-aminopyridine; 3-AP; 3-pyridylamine m-aminopyridine; amino-3-pyridine; ß-pyridylamine

OSHA IMIS Code Number: A174

Chemical Abstracts Service (CAS) Registry Number: 462-08-8

Chemical Description and Physical Properties:

white to light yellow-brown crystals with characteristic unpleasant odor
molecular formula: C5H6N2
molecular weight: 94.13
boiling point: 251°C (484°F)
flash point: 88°C (190°F) closed cup
solubility: soluble in water, alcohol, ether
melting point: 64°C (147°F)
Health Factors

Potential Symptoms: Irritation of eyes (redness, pain), skin (redness, pain), respiratory tract, and digestive tract; headache, nausea, increased blood pressure, weakness; tremor, excitability, convulsions, stupor.

Health Effects: Poisonous (HE4); Convulsions (HE7); Irritation-Eyes, Nose, Throat, Skin---Marked (HE14)

Affected Organs: CNS, eyes, skin

Notes:

  1. OSHA does not have a PEL for 3-aminopyridine, which may be fatal if absorbed through the skin or swallowed.
  2. 3-Aminopyridine is a potassium channel blocker used as a research tool to induce seizures in experimental animal models of epilepsy.

Date Last Revised: 09/19/2006

Literature Basis:

  • Acros Organics N.V.: Material Safety Data Sheet: 3-Aminopyridine, 99%.
  • Galvan, M., Franz, P. and Vogel-Weins, C.: Actions of potassium channel blockers on guinea-pig lateral olfactory tract axons. Naunyn-Schmiedebergs Arch. Pharmacol. 325(1): 8-11, 1984.
  • Riker, W.K., Matsumoto, M. and Takashima, K.: Synaptic facilitation by 3-aminopyridine and its antagonism by verapamil and diltiazem. J. Pharmacol. Exp. Ther. 235(2): 431-435, 1985.
  • Slezia, A., et al.: Uridine release during aminopyridine-induced epilepsy. Neurobiol. Dis. 16(3): 490-499, 2004.
Monitoring Methods used by OSHA

Primary Laboratory Sampling/Analytical Method (SLC1):

  • sampling media: three-piece cassettes containing two sulfuric acid-treated glass fiber filters separated by a spacer in a closed face cassette
    analytical solvent: 0.1 N NaOH
    maximum volume: 240 Liters
    maximum flow rate: 1.0 L/min
    current analytical method: Gas Chromatography; GC/NPD
    method reference: OSHA Analytical Method (OSHA PV2143)
    method classification: Partially Validated
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