Potential symptoms: Irritation of eyes, skin, respiratory system; cough, sore throat, shortness of breath, pulmonary edema (may be delayed); skin pain, redness, burns, blisters; eye pain, redness, burns, loss of vision; INGES. ACUTE: Burning sensation; abdominal cramps; shock or collapse.
Health Effects: Irritation-Eye, Nose, Throat, Skin---Marked (HE14); Pulmonary edema (HE11).
Affected organs: Skin, eyes, respiratory system
OSHA does not have a PEL for 1-amino-2-propanol. An occupational exposure limit of 7.3 mg/m3 has been proposed, being 1/60 of the concentration causing a 50% decrease in respiratory frequency due to respiratory irritation in mice exposed for 3 hours.
Vapor/air mixtures of 1-amino-2-propanol may be explosive at temperatures above 77°C.
1-Amino-2-propanol is considered to have no safety concern at current levels of intake when used as a flavoring agent [Flavor and Extract Manufacturers Association number 3130; Joint FAO/WHO Expert Committee on Food Additives (JECFA) number 1582]. JECFA may revoke this status if use levels as a flavoring agent or poundage data remain unknown by the end of 2007.
Exposure of the skin to a 2% solution may be slightly irritating, but did not cause sensitization in any of 150 volunteers.
Five cases of irritant contact dermatitis were found during a NIOSH evaluation of some employees exposed to monoisopropanolamine at a plant that produces titanium dioxide pigment.