Synonyms: AMP; 2-aminodimethylethanol; ß-aminoisobutanol; 2-amino-2-methylpropan-1-ol; 2-amino-2-methyl-1-propanol; isobutanol-2-amine; isobutanolamine

OSHA IMIS Code Number: A615

Chemical Abstracts Service (CAS) Registry Number: 124-68-5

NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: UA5950000

Chemical Description and Physical Properties:

clear liquid
molecular weight: 89.14
vapor pressure: ≤ 1 mmHg @ 25°C
molecular formula: C₄H₁₁NO
boiling point: 165°C
flash point: 68°C closed cup
melting point: 30-31°C
density: 0.934

Potential Symptoms: Irritation of eyes, skin, respiratory tract; cough, sore throat; pulmonary edema (may be delayed); eye pain, redness, severe deep burns (on contact with liquid); skin redness, pain; INGES. ACUTE: Burning sensation, abdominal pain

Health Effects: Irritation-Eyes, Nose, Throat, Skin---Marked (HE14); Pulmonary edema (HE4)

Affected Organs: Eyes, skin, respiratory system

Notes:

1. OSHA does not have a PEL for 2-amino-2-methylpropanol (AMP), although an exposure limit of 10.7 mg/m3 has been estimated from pulmonary irritation studies in mice.
2. Vapor/air mixtures of AMP may be explosive above 67°C.
3. Rats injected with radiolabeled AMP excreted it unchanged in the urine, but also incorporated some of the radioactivity into phospholipids.
4. On the basis of a number of inhalational and dermal studies of cosmetic and hair spray formulations containing not more than 1% AMP, an expert panel of the Cosmetic Ingredient Review Board recommended that AMP is safe as a cosmetic ingredient at concentrations not exceeding 1%.
5. Periorbital edema and facial erythema were reported for two employees exposed to AMP during hair dye production. Patch tests of these and other employees at this cosmetic company caused erythema and edema without blistering at 10 and 20% dilutions of AMP in water or ethanol, indicating the potential to cause irritative contact dermatitis at these AMP concentrations.

Date Last Revised: 02/26/2007

Literature Basis:

• International Chemical Safety Cards (WHO/IPCS/ILO): Isobutanolamine.
• Cipolla, C., et al.: Airborne contact dermatitis from 2-amino-2-methyl-1-propanol in a cosmetic company. Arh. Hig. Rada Toksikol. 48(2): 205-209, 1997.
• Cosmetic Ingredient Review Board: A final report on the safety assessment of aminomethylpropanol and aminomethylpropanediol. J. Am. Coll. Toxicol. 9(2): 203-228, 1990.
• Detwiler-Okabayashi, K.A. and Schaper, M.M.: Respiratory effects of a synthetic metalworking fluid and its components. Arch. Toxicol. 70(3-4): 195-201, 1996.
• Yue, K.T., Mulford, D.J. and Russell, P.J.: The metabolism of 2-amino-2-methylpropanol in young rats. Arch. Biochem. Biophys. 136(1): 47-53, 1970.

Primary Laboratory Sampling/Analytical Method (SLC1):

• sampling media: Coated XAD-2 Tube (80/40 sections, 20/60 mesh); coating is 10% (w/w) 1-Naphthylisothiocyanate (NITC)
  analytical solvent: Dimethylformamide
  maximum volume: 10 Liters
  maximum flow rate: 0.1 L/min (TWA)
  maximum volume: 1.5 Liters   
  maximum flow rate: 0.1 L/min (STEL)
  current analytical method: High Performance Liquid Chromatography; HPLC/UV
  method reference: OSHA Analytical Method (OSHA PV2145)
  method classification: Partially Validated
  

** All Trademarks are the property of their respective owners.