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Chemical Sampling Information |
| Allyl glycidyl ether |
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General Description
Synonyms: AGE; 1-Allyloxy-2,3-epoxypropane; Composite Constituent; Glycidyl allyl ether; [(2-Propenyloxy)methyl] oxirane
OSHA IMIS Code Number: 0145
Chemical Abstracts Service (CAS) Registry Number: 106-92-3
NIOSH, Registry of Toxic Effects (RTECS) Identification Number: RR0875000
Department of Transportation Regulation Number (49 CFR 172.101) and Guide: 2219 129 [27 KB, PDF]
NIOSH Pocket Guide to Chemical Hazards, Allyl glycidyl ether: chemical description, physical properties, potentially hazardous incompatibilities, and more
Exposure Limits
OSHA Permissible Exposure Limit (PEL) for General Industry: 29 CFR 1910.1000 Z-1 Table -- 10 ppm, 45 mg/m3 Ceiling
OSHA Permissible Exposure Limit (PEL) for Construction Industry: 29 CFR 1926.55 Appendix A -- 10 ppm, 45 mg/m3 Ceiling
OSHA Permissible Exposure Limit (PEL) for Maritime: 29 CFR 1915.1000 Table Z-Shipyards -- 10 ppm, 45 mg/m3 Ceiling
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 1 ppm, 5 mg/m3 TWA; Appendix A4 - Not Classifiable as a Human Carcinogen
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 5 ppm, 22 mg/m3 TWA; 10 ppm, 44 mg/m3 STEL; Skin
Health Factors
NIOSH Immediately Dangerous To Life or Health Concentration (IDLH): 50 ppm
Potential symptoms: ): Irritation of eyes, skin, nose, respiratory system; pulmonary edema; narcosis; skin redness, pain, blisters; eye redness, pain, burns, blurred vision; dermatitis; possible hematopoietic, reproductive effects; INGES. ACUTE: Burning sensation, dullness, drowsiness, headache, nausea, vomiting
Health Effects: : Irritation – Eyes, nose, throat, bronchi, skin---Marked (HE14); Mutagenic (HE2).
Affected organs: Eyes, skin, respiratory system, blood, reproductive system.
Notes:
- Vapor/air mixtures of allyl glycidyl ether may be explosive above 48°C.
- Application of 4 mg of allyl glycidyl ether in acetone to the skin of mice resulted in adduct formation with the N-terminal valine in hemoglobin to form N-(2-hydroxy-3-(2,3-dihydroxy)propylvaline.
- Adducts with DNA, primarily at the N-7-guanine and N-1-adenine positions, have also been reported after application of allyl glycidyl ether to the skin of mice.
- Occupational allergic contact dermatitis from allyl glycidyl ether has been reported.
Date Last Revised: 06/25/2007
Literature Basis:
- NIOSH Pocket Guide to Chemical Hazards: Allyl glycidyl ether.
- International Chemical Safety Cards (WHO/IPCS/ILO): Allyl glycidyl ether.
- Dooms-Goossens, A., Bruze, M., Buysse, L., Fregert, S., Gruvberger, B. and Stals, H.: Contact allergy to allyl glycidyl ether present as an impurity in 3-glycidyloxypropyltrimethoxysilane, a fixing additive in silicone and polyurethane resins. Contact Dermatitis 33(1): 17-19, 1995.
- National Toxicology Program: NTP Toxicology and Carcinogenesis Studies of Allyl Glycidyl Ether (CAS No. 106-92-3) in Osborne-Mendel Rats and B6C3F1 Mice (Inhalational Studies). Natl. Toxicol. Program Tech. Rep. Ser. 376: 1-219, 1990.
- Pérez, H.L. and Osterman-Golkar, S.: Biotransformation of the double bond in allyl glycidyl ether to an epoxide ring. Evidence from hemoglobin adducts in mice. Chem. Biol. Interact. 125(1): 17-28, 2000.
- Pina, K. and Segerbäch, D.: 32P-Postlabeling of DNA adducts formed by allyl glycidyl ether in vitro and in vivo. Carcinogenesis 18(8): 1457-1462, 1997.
- Pohanish, R.P. (editor): Allyl Glycidyl Ether. In, Sittig’s Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 101-103.
Monitoring Methods used by OSHA
Laboratory Sampling/Analytical Method:
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sampling media: Tenax-GC Tube (100/50 mg sections, 35/60 mesh)
analytical solvent: Diethyl ether
maximum volume: 3 Liters maximum flow rate: 0.2 L/min (TWA)
maximum volume: 3 Liters maximum flow rate: 0.2 L/min (STEL)
minimum time: 15 Minutes maximum flow rate: 0.2 L/min (Ceiling)
current analytical method: Gas Chromatography; GC/FID
method reference: NIOSH Analytical Method (NIOSH 2545) [20 KB, PDF]
method classification: Fully Validated
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