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Safety and Health Topics: |
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| Adipic Acid |
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General Description
Synonyms: Acifloctin; Acinetten; Adilatetten; Adipinic Acid; 1,4-Butanedicarboxylic Acid; 1,6-Hexanedioic Acid
OSHA IMIS Code Number: A155
Chemical Abstracts Service (CAS) Registry Number: 124-04-9
NIOSH, Registry of Toxic Effects (RTECS) Identification Number: AU8400000
Chemical Description and Physical Properties: Freely soluble in methanol, ethanol; soluble in acetone
molecular formula: C6H10O4
molecular weight: 146.16
boiling point: 338°C
vapor pressure: Pa at 18.5°C: 10
melting point: 152°C
density: 1.36 g/ml
Exposure Limits
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 5 mg/m3
Health Factors
Potential symptoms: Irritation eyes, respiratory system; cough, sore throat, asthma; contact dermatitis.
Health Effects: Irritation-Eyes, Nose, Throat---Mild (HE16); Respiratory effects---asthma (HE9)
Affected organs: Eyes, skin, respiratory system
Notes: 1) There is no OSHA PEL for adipic acid. It is on FDA's list of food additives that are "Generally Recognized as Safe" (21CFR 184.1009). 2) A single intratracheal instillation in rats caused persistent lung alterations, including pulmonary fibrosis (Kennedy, 2002).
Date Last Revised: 01/15/2004
Literature Basis:
- International Chemical Safety Cards (WHO/IPCS/ILO): Adipic acid.
- Kennedy, G.L., Jr.: Toxicity of adipic acid. Drug Chem. Toxicol. 25(2): 191-202, 2002.
Monitoring Methods used by OSHA
Laboratory Sampling/Analytical Method:
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sampling media: OSHA Versatile Sampler (OVS-2) - 13 mm XAD-2 tube (270/140 mg sections, 20/60 mesh) with a Glass Fiber Filter enclosed
analytical solvent: Methanol
maximum volume: 100 Liters maximum flow rate: 0.2 L/min
current analytical method: Gas Chromatography; GC/FID
method reference: OSHA SLTC In-House File
method classification: Not Validated
analytical conditions: Column: 15 m x 0.32 mm ID Stabilwax 1 micron film Temp: Oven 200 - 210° deg C; Inj 220° deg C; Det 220° deg C
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| Revised: 14 May 2004 |
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