Section 5(a)(1) of the OSH Act, often referred to as the General Duty Clause, requires employers to "furnish to each of his employees employment and a place of employment which are free from recognized hazards that are causing or are likely to cause death or serious physical harm to his employees". Section 5(a)(2) requires employers to "comply with occupational safety and health standards promulgated under this Act".

General Industry (29 CFR 1910)

• 1910 Subpart H, Hazardous materials [related topic page]
  • 1910.106, Flammable and combustible liquids
  • 1910.119, Process safety management of highly hazardous chemicals [related topic page]
    • Appendix A, List of highly hazardous chemicals, toxics and reactives (Mandatory)
    • Appendix B, Block flow diagram and simplified process flow diagram (Non-mandatory)
    • Appendix C, Compliance guidelines and recommendations for process safety management (Non-mandatory)
    • Appendix D, Sources of further information (Non-mandatory)
  • 1910 Subpart L, Fire protection [related topic page]
    • 1910.156, Fire brigades
  • 1910 Subpart Z, Toxic and hazardous substances [related topic page]
    • 1910.1200, Hazard communication [related topic page]
    • 1910.1450, Occupational exposure to hazardous chemicals in laboratories

Construction Industry (29 CFR 1926)

• 1926 Subpart D, Occupational health and environmental controls
  • 1926.59, Hazard communication
  • 1926.64, Process safety management of highly hazardous chemicals
    • Appendix A, List of highly hazardous chemicals, toxics and reactives (Mandatory)
    • Appendix B, Block flow diagram and simplified process flow diagram (Non-mandatory)
    • Appendix C, Compliance guidelines and recommendations for process safety management (Non-mandatory)
    • Appendix D, Sources of further information (Non-mandatory)

• Process Safety Management (1992)
• Search all available preambles to final rules.

• Inspection Procedures for the Hazard Communication Standard. CPL 02-02-038 [CPL 2-2.38D], (1998, March 20). Establishes policies and provides clarifications to ensure uniform enforcement of the Hazard Communication Standard (HCS).
• Process Safety Management (PSM) of Highly Hazardous Chemicals – Compliance Guidelines and Enforcement Procedures. CPL 02-02-045 [CPL 2-2.45A CH-1], (1994, September 13). Contains page changes to Instruction CPL 2-2.45A, which established uniform policies, procedures, standard clarifications, and compliance guidance for enforcement of the standard for PSM of Highly Hazardous Chemicals, 29 CFR 1910.119, and amendments to the standard for Explosives and Blasting Agents, 29 CFR 1910.109. (Note: Some original CPL and audit guidelines are not included in this document).
• OSHA Response to Significant Events of Potentially Catastrophic Consequences. CPL 02-00-094 [CPL 2.94], (1991, July 22). It is OSHA policy to respond as quickly as possible to significant events which may affect the health or safety of employees including chemical incidents.
• Search all available directives.

• 49 CFR 100-185, Subtitle B--Other Regulations Relating to Transportation.
  • Research and Special Programs Administration. Includes a Segregation Table for Hazardous Materials under section 177.848.

• 40 CFR 68, Protection of the Environment: Chemical Accident Prevention Provisions. Also available as a 128 KB PDF, 55 pages. Includes a list of regulated substances and thresholds, the petition process for adding or deleting substances to/from the list of regulated substances, the requirements for owners or operators of stationary sources concerning the prevention of accidental releases, and approved state accidental release prevention programs.